Dr. Antoine-Emmanuel Saliba
Über
Antoine-Emmanuel Saliba studierte Bioverfahrenstechnik am Institut National des Sciences Appliqués (INSA) in Toulouse (Frankreich) und promovierte in der Forschungsgruppe von Jean-Louis Viovy am Institut Curie in Paris. Er setzte mikrofluidbasierte Systeme zur Sortierung und Analyse seltener Subpopulationen von Krebszellen ein. Anschließend arbeitete er als Stipendiat der interdisziplinären Postdoc Initiative (EIPOD) des Europäischen Laboratoriums für Molekularbiologie (EMBL) in Heidelberg. Dort war er an der Entwicklung innovativer systembiologischer Ansätze zur Analyse von Protein-Lipid-Wechselwirkungen beteiligt. Als Postdoc kam er anschließend ans Labor von Jörg Vogel in Würzburg und etablierte dort die Technologie der Einzelzell-RNA-Sequenzierung. Mit deren Hilfe verfolgte er beispielsweise das Schicksal einzelner Zellen während einer Infektion mit Salmonella enterica. Seit 2017 leitet er die Gruppe Einzelzellanalyse am HIRI.
2023
Advancing massive transcriptional profiling of single bacteria
Saliba AE (2023)
Cell Reports Methods 3 (2): 100416DOI: 10.1016/j.crmeth.2023.100416
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection
Däullary T, Imdahl F, Dietrich O, Hepp L, Krammer T, Fey C, Neuhaus W, Metzger M, Vogel J, Westermann AJ, Saliba AE, Zdzieblo D (2023)
Gut Microbes 15 (1): 2186109DOI: 10.1080/19490976.2023.2186109
Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma
Leipold AM, Werner RA, Düll J, Jung P, John M, Stanojkovska E, Zhou X, Hornburger H, Ruckdeschel A, Dietrich O, …, Saliba AE, Rasche L (2023)
Leukemia (Online ahead of print)DOI: 10.1038/s41375-023-01824-0
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells
Delgobo M, Weiß E, ElDin Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer PP, …, Frantz S, Campos Ramos G (2023)
Circulation Research 132 (5): 565-582DOI: 10.1161/CIRCRESAHA.122.322183
Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19
Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, …, Schulte LN, Li Y (2023)
Cell Genomics 3 (2): 100232DOI: 10.1016/j.xgen.2022.100232
A MATQ-seq-Based Protocol for Single-Cell RNA-seq in Bacteria
Homberger C, Saliba AE, Vogel J (2023)
Methods in Molecular Biology 2584: 105-121DOI: 10.1007/978-1-0716-2756-3_4
2022
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
Al-Rifai R, Vandestienne M, Lavillegrand JR, Mirault T, Cornebise J, Poisson J, Laurans L, Esposito B, James C, Mansier O, …, Rautou PE, Ait-Oufella H (2022)
Nature Communications 13 (1): 6592DOI: 10.1038/s41467-022-34469-1
Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets
Pezoldt J, Wiechers C, Zou M, Litovchenko M, Biocanin M, Beckstette M, Sitnik K, Palatella M, van Mierlo G, Chen W, …, Deplancke B, Huehn J (2022)
Nature Communications 13 (1): 7227DOI: 10.1038/s41467-022-34868-4
Time-resolved single-cell RNA-seq using metabolic RNA labelling
Erhard F, Saliba AE, Lusser A (2022)
Nature Reviews Methods Primers 2 (1): 331DOI: 10.1038/s43586-022-00157-z
Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
Zernecke A, Erhard F, Weinberger T, Schulz C, Ley K, Saliba AE, Cochain C (2022)
Cardiovascular Research (Online ahead of print)DOI: 10.1093/cvr/cvac161
Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis
Aguilar C, Pauzuolis M, Pompaiah M, Vafadarnejad E, Arampatzi P, Fischer M, Narres D, Neyazi M, Kayisoglu Ö, Sell T, …, Saliba AE, Bartfeld S (2022)
Nature Communications 13 (1): 5878DOI: 10.1038/s41467-022-33165-4
Eine Einzelzell-RNA-Sequenzierung identifiziert Metabolismus und CD52 als neue Angriffspunkte in Ibrutinib-persistenten Mantelzelllymphomzellen
Fuhr V, Vafadarnejad E, Dietrich O, Arampatzi P, Riedel A, Saliba AE, Rosenwald A, Rauert-Wunderlich H (2022)
Die Pathologie 43 (1): 31DOI: 10.1007/s00292-022-01136-7
Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells
Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le DD, Peña Mosca J, Arellano-Viera E, Kern MA, Graf C, Beyersdorf N, …, Huehn J, Beilhack A (2022)
JCI Insight 7 (22)DOI: 10.1172/jci.insight.154250
Landscape and age dynamics of immune cells in the Egyptian rousette bat
Friedrichs V, Toussaint C, Schäfer A, Rissmann M, Dietrich O, Mettenleiter TC, Pei G, Balkema-Buschmann A, Saliba AE, Dorhoi A (2022)
Cell Reports 40 (10): 111305DOI: 10.1016/j.celrep.2022.111305
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction
Rizzo G, Gropper J, Piollet M, Vafadarnejad E, Rizakou A, Bandi SR, Arampatzi P, Krammer T, DiFabion N, Dietrich O, …, Saliba AE, Cochain C (2022)
Cardiovascular Research (Online ahead of print)DOI: 10.1093/cvr/cvac113
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responses
Kazmierski J, Friedmann K, Postmus D, Emanuel J, Fischer C, Jansen J, Richter A, Bosquillon de Jarcy L, Schüler C, Sohn M, …, Niemeyer D, Goffinet C (2022)
Molecular Systems Biology 18 (8): 10961DOI: 10.15252/msb.202210961
Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes
Ataide MA, Knöpper K, Cruz de Casas P, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Yang T, …, Gasteiger G, Kastenmüller W (2022)
Immunity 55 (10): 1813DOI: 10.1016/j.immuni.2022.07.019
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, …, Sawitzki B, PA-COVID-19 Study Group (2022)
Cell 185 (3): 493-512DOI: 10.1016/j.cell.2021.12.040
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
Dähling S, Mansilla AM, Knöpper K, Grafen A, Utzschneider DT, Ugur M, Whitney PG, Bachem A, Arampatzi P, Imdahl F, …, Bedoui S, Kastenmüller W (2022)
Immunity 55 (4): 656-670DOI: 10.1016/j.immuni.2022.03.006
Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice
Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, …, Cochain C, Zernecke A (2022)
Cardiovascular Research 118 (14): 2932-2945DOI: 10.1093/cvr/cvab359
Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles
Akbar N, Braithwaite AT, Corr EM, Koelwyn GJ, van Solingen C, Cochain C, Saliba AE, Corbin A, Pezzolla D, Møller Jørgensen M, …, Melling GE, Shanmuganathan M (2022)
Cardiovascular Research (Online ahead of print)DOI: 10.1093/cvr/cvac012