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Prof. Chase Beisel

Über

Seit seiner Doktorarbeit 2009 im Fach Chemieingenieurwesen am California Institute of Technology (Pasadena, USA) befasst sich Chase Beisel mit Fragen des RNA-Engineering. Nach zwei Jahren an den National Institutes of Health (Bethesda, Maryland, USA) begann er 2011 seine Fakultätstätigkeit in der Abteilung für chemische und biomolekulare Verfahrenstechnik an der North Carolina State University (Raleigh, North Carolina, USA), wo er sich mit RNA-gesteuerten Immunsystemen, so genannten CRISPR-Cas-Systemen, beschäftigte und zum Associate Professor (Tenure) befördert wurde. Seit 2018 forscht er am HIRI im Bereich RNA-Engineering, mit dem Ziel, Infektionskrankheiten besser zu verstehen, zu diagnostizieren und zu behandeln. 


2022

Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases

Wandera KG, Alkhnbashi OS, Bassett HVI, Mitrofanov A, Hauns S, Migur A, Backofen R, Beisel CL (2022)

Molecular Cell (Online ahead of print)DOI: 10.1016/j.molcel.2022.05.003

Reprogramming TracrRNAs for Multiplexed RNA Detection

Jiao C, Beisel CL (2022)

Methods in Molecular Biology 2518: 217-235DOI: 10.1007/978-1-0716-2421-0_13

A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13

Vialetto E, Yu Y, Collins SP, Wandera KG, Barquist L, Beisel CL (2022)

Cell Host & Microbe 3128 (22): 00273-6DOI: 10.1016/j.chom.2022.05.013

Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins

Gallo M, Vento JM, Joncour P, Quagliariello A, Maritan E, Silva-Soares NF, Battistolli M, Beisel CL, Martino ME (2022)

iScience 25 (6): 104357DOI: 10.1016/j.isci.2022.104357

Genome Editing with Cas9 in Lactobacilli

Vento JM, Beisel CL (2022)

Methods in Molecular Biology 2479: 245-261DOI: 10.1007/978-1-0716-2233-9_16

CRISPR memories in single cells

Sparmann A, Beisel CL (2022)

Molecular Systems Biology 18 (4): 11011DOI: 10.15252/msb.202211011

Rapidly Characterizing CRISPR-Cas13 Nucleases Using Cell-Free Transcription-Translation Systems

Wandera KG, Beisel CL (2022)

Methods in Molecular Biology 2404: 135-153DOI: 10.1007/978-1-0716-1851-6_7

Differentially Optimized Cell-Free Buffer Enables Robust Expression from Unprotected Linear DNA in Exonuclease-Deficient Extracts

Batista AC, Levrier A, Soudier P, Voyvodic PL, Achmedov T, Reif-Trauttmansdorff T, DeVisch A, Cohen-Gonsaud M, Faulon JL, Beisel CL, Bonnet J, Kushwaha M (2022)

ACS Synthetic Biology 11 (2): 732-746DOI: 10.1021/acssynbio.1c00448

A TXTL-Based Assay to Rapidly Identify PAMs for CRISPR-Cas Systems with Multi-Protein Effector Complexes

Wimmer F, Englert F, Beisel CL (2022)

Methods in Molecular Biology 2433: 391-411DOI: 10.1007/978-1-0716-1998-8_24

Rapid cell-free characterization of multi-subunit CRISPR effectors and transposons

Wimmer F, Mougiakos I, Englert F, Beisel CL (2022)

Molecular Cell 82 (6): 1210-1224DOI: 10.1016/j.molcel.2022.01.026

Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA

Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL (2022)

Nature Microbiology 7 (4): 530-541DOI: 10.1038/s41564-022-01074-3

2021

Coupling smartphone and CRISPR–Cas12a for digital and multiplexed nucleic acid detection

Yu T, Zhang S, Matei R, Marx W, Beisel CL, Wei Q (2021)

American Institute of Chemical Engineers Journal 67 (12): 17399DOI: 10.1002/aic.17365

Illuminating the path to DNA repair

Gupta D, Beisel CL (2021)

Cell 184 (22): 5503-5505DOI: 10.1016/j.cell.2021.10.005

The tracrRNA in CRISPR Biology and Technologies

Liao C, Beisel CL (2021)

Annual Review of Genetics 55: 161-181DOI: 10.1146/annurev-genet-071719-022559

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Taxiarchi C, Beaghton A, Don NI, Kyrou K, Gribble M, Shittu D, Collins SP, Beisel CL, Galizi R, Crisanti A (2021)

Nature Communications 12 (1): 3977DOI: 10.1038/s41467-021-24214-5

CRISPR transposons on the move

Mougiakos I, Beisel CL (2021)

Cell Host & Microbe 29 (5): 675-677DOI: 10.1016/j.chom.2021.04.012

Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9

Jiao C, Sharma S, Dugar G, Peeck NL, Bischler T, Wimmer F, Yu Y, Barquist L, Schoen C, Kurzai O, Sharma CM, Beisel CL (2021)

Science 372 (6545): 941-948DOI: 10.1126/science.abe7106

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

Durmusoglu D, Al'Abri IS, Collins SP, Cheng J, Eroglu A, Beisel CL, Crook N (2021)

ACS Synthetic Biology 10 (5): 1039-1052DOI: 10.1021/acssynbio.0c00562

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR-Cas12a gRNA switch

Collins SP, Rostain W, Liao C, Beisel CL (2021)

Nucleic Acids Research 49 (5): 2985-2999DOI: 10.1093/nar/gkab100

A Code of Ethics for Gene Drive Research

Annas GJ, Beisel CL, Clement K, Crisanti A, Francis S, Galardini M, Galizi R, Grünewald J, Immobile G, Khalil AS, …, Taxiarchi C, Joung JK (2021)

The CRISPR journal 4 (1): 19-24DOI: 10.1089/crispr.2020.0096

CRISPR technologies and the search for the PAM-free nuclease

Collias D, Beisel CL (2021)

Nature Communications 12 ((1)): 555DOI: 10.1038/s41467-020-20633-y