Prof. Chase Beisel


Seit seiner Doktorarbeit 2009 im Fach Chemieingenieurwesen am California Institute of Technology (Pasadena, USA) befasst sich Chase Beisel mit Fragen des RNA-Engineering. Nach zwei Jahren an den National Institutes of Health (Bethesda, Maryland, USA) begann er 2011 seine Fakultätstätigkeit in der Abteilung für chemische und biomolekulare Verfahrenstechnik an der North Carolina State University (Raleigh, North Carolina, USA), wo er sich mit RNA-gesteuerten Immunsystemen, so genannten CRISPR-Cas-Systemen, beschäftigte und zum Associate Professor (Tenure) befördert wurde. Seit 2018 forscht er am HIRI im Bereich RNA-Engineering, mit dem Ziel, Infektionskrankheiten besser zu verstehen, zu diagnostizieren und zu behandeln. 


A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Taxiarchi C, Beaghton A, Don NI, Kyrou K, Gribble M, Shittu D, Collins SP, Beisel CL, Galizi R, Crisanti A (2021)

Nature Communications 12 (1): 3977DOI: 10.1038/s41467-021-24214-5

CRISPR transposons on the move

Mougiakos I, Beisel CL (2021)

Cell Host & Microbe 29 (5): 675-677DOI: 10.1016/j.chom.2021.04.012

Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9

Jiao C, Sharma S, Dugar G, Peeck NL, Bischler T, Wimmer F, Yu Y, Barquist L, Schoen C, Kurzai O, Sharma CM, Beisel CL (2021)

Science 372 (6545): 941-948DOI: 10.1126/science.abe7106

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

Durmusoglu D, Al'Abri IS, Collins SP, Cheng J, Eroglu A, Beisel CL, Crook N (2021)

ACS Synthetic Biology 10 (5): 1039-1052DOI: 10.1021/acssynbio.0c00562

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR-Cas12a gRNA switch

Collins SP, Rostain W, Liao C, Beisel CL (2021)

Nucleic Acids Research 49 (5): 2985-2999DOI: 10.1093/nar/gkab100

A Code of Ethics for Gene Drive Research

Annas GJ, Beisel CL, Clement K, Crisanti A, Francis S, Galardini M, Galizi R, Grünewald J, Immobile G, Khalil AS, …, Taxiarchi C, Joung JK (2021)

The CRISPR journal 4 (1): 19-24DOI: 10.1089/crispr.2020.0096

CRISPR technologies and the search for the PAM-free nuclease

Collias D, Beisel CL (2021)

Nature Communications 12: 555DOI: 10.1038/s41467-020-20633-y


Rapid Testing of CRISPR Nucleases and Guide RNAs in an E. coli Cell-Free Transcription-Translation System

Marshall R, Beisel CL, Noireaux V (2020)

STAR Protocols 1 (1): 10000DOI: 10.1016/j.xpro.2019.100003

A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9

Collias D, Leenay RT, Slotkowski RA, Zuo Z, Collins SP, McGirr BA, Liu J, Beisel CL (2020)

Science Advances 6 (29): 4054DOI: 10.1126/sciadv.abb4054

Your Base Editor Might Be Flirting with Single (Stranded) DNA: Faithful On-Target CRISPR Base Editing without Promiscuous Deamination

Collins SP, Beisel CL (2020)

Molecular Cell 79 (5): 703-704DOI: 10.1016/j.molcel.2020.07.030

Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs

Jacobsen T, Ttofali F, Liao C, Manchalu S, Gray BN, Beisel CL (2020)

Nucleic Acids Research 48 (10): 5624-5638DOI: 10.1093/nar/gkaa272

Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

Jacobsen T, Yi G, Al Asafen H, Jermusyk AA, Beisel CL, Reeves GT (2020)

PLOS One 15 (4): 02320DOI: 10.1371/journal.pone.0232046

Competitive exclusion is a major bioprotective mechanism of lactobacilli against fungal spoilage in fermented milk products

Siedler S, Rau MH, Bidstrup S, Vento JM, Aunsbjerg SD, Bosma EF, McNair LM, Beisel CL, Neves AR (2020)

Applied and Environmental Microbiology 86 (7): 02312-19DOI: 10.1128/AEM.02312-19

Methods for characterizing, applying, and teaching CRISPR-Cas systems

Beisel CL (2020)

Methods 172: 1-2DOI: 10.1016/j.ymeth.2020.01.004

CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers

Wimmer F, Beisel CL (2020)

Frontiers in Microbiology 10: 3078DOI: 10.3389/fmicb.2019.03078