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Prof. Jörg Vogel

Über

Prof. Jörg Vogel ist seit 2017 Direktor des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) in Würzburg, wo er schon seit 2009 als Professor und Direktor des Instituts für Molekulare Infektionsbiologie (IMIB) tätig war. Als weltweit anerkannter Wissenschaftler auf dem Gebiet der RNA-Biologie, 2017 mit dem Leibniz-Preis ausgezeichnet, gilt er als Pionier in der Anwendung und Entwicklung von Hochdurchsatz-Sequenziermethoden für die Analyse einzelner infizierter Zellen sowie von Interaktionen zwischen krankheitserregenden Bakterien und ihren Wirten. Er studierte Biochemie an der Humboldt-Universität zu Berlin und am Imperial College, London (GB). 1999 promovierte er an der Humboldt-Universität mit einer Dissertation über
Gruppe II-Intronspleißen . Er forschte 2000/2001 an der Universität Uppsala (Schweden) und 2002/2003 als EMBO-Fellow an der Hebrew University, Jerusalem (Israel), bevor er 2004 eine unabhängige Nachwuchsgruppe am Max-Planck-Institut für Infektionsbiologie in Berlin gründete. 


2022

An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs

Schneider C, Erhard F, Binotti B, Buchberger A, Vogel J, Fischer U (2022)

Cell Reports 41 (2): 111467DOI: 10.1016/j.celrep.2022.111467

INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors

Hör J, Jung J, Ðurica-Mitic S, Barquist L, Vogel J (2022)

Nucleic Acids Research (Online ahead of print)DOI: 10.1093/nar/gkac838

Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum

Ponath F, Zhu Y, Cosi V, Vogel J (2022)

PNAS 119 (40): 2201460DOI: 10.1073/pnas.2201460119

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, Bremser A, Polyzou A, Obier N, Cabezas-Wallscheid N, …, Westermann AJ, Rambold AS (2022)

Nature Metabolism 4 (7): 856-866DOI: 10.1038/s42255-022-00605-w

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

Popella L, Jung J, Do PT, Hayward RJ, Barquist L, Vogel J (2022)

Nucleic Acids Research 50 (11): 6435DOI: 10.1093/nar/gkac362

Cellular RNA Targets of Cold Shock Proteins CspC and CspE and Their Importance for Serum Resistance in Septicemic Escherichia coli

Yair Y, Michaux C, Biran D, Bernhard J, Vogel J, Barquist L, Ron EZ (2022)

mSystems 7 (4): 0008622DOI: 10.1128/msystems.00086-22

An overview of gene regulation in bacteria by small RNAs derived from mRNA 3' ends

Ponath F, Hör J, Vogel J (2022)

FEMS Microbiology Reviews 46 (5): 017DOI: 10.1093/femsre/fuac017

Global RNA interactome of Salmonella discovers a 5' UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity

Matera G, Altuvia Y, Gerovac M, El Mouali Y, Margalit H, Vogel J (2022)

Molecular Cell 82 (3): 629-644DOI: 10.1016/j.molcel.2021.12.030

The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner

Gomez-Raya-Vilanova MV, Leskinen K, Bhattacharjee A, Virta P, Rosenqvist P, Smith JLR, Bayfield OW, Homberger C, Kerrinnes T, Vogel J, Pajunen MI, Skurnik M (2022)

Nucleic Acids Research 50 (7): 3985-3997DOI: 10.1093/nar/gkac203

Innovative developments and emerging technologies in RNA therapeutics

Halloy F, Biscans A, Bujold KE, Debacker A, Hill AC, Lacroix A, Luige O, Strömberg R, Sundstrom L, Vogel J, Ghidini A (2022)

RNA Biology 19 (1): 313-332DOI: 10.1080/15476286.2022.2027150

2021

Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production

Lamm-Schmidt V, Fuchs M, Sulzer J, Gerovac M, Hör J, Dersch P, Vogel J, Faber F (2021)

microLife 2: 3704DOI: 10.1093/femsml/uqab004

Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E

Islam MS, Bandyra KJ, Chao Y, Vogel J, Luisi BF (2021)

RNA 27 (11): 1339-1352DOI: 10.1261/rna.078840.121

SPI2 T3SS effectors facilitate enterocyte apical to basolateral transmigration of Salmonella-containing vacuoles in vivo

Fulde M, van Vorst K, Zhang K, Westermann AJ, Busche T, Huei YC, Welitschanski K, Froh I, Pägelow D, Plendl J, …, Repnik U, Hornef MW (2021)

Gut Microbes 13 (1): 1973836DOI: 10.1080/19490976.2021.1973836

Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease

El Mouali Y, Ponath F, Scharrer V, Wenner N, Hinton JCD, Vogel J (2021)

RNA 27 (12): 1512-1527DOI: 10.1261/rna.078954.121

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium

Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J, Faber F (2021)

PNAS 118 (25): 2103579DOI: 10.1073/pnas.2103579118

RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum

Ponath F, Tawk C, Zhu Y, Barquist L, Faber F, Vogel J (2021)

Nature Microbiology 6 (8): 1007-1020DOI: 10.1038/s41564-021-00927-7

The World of Stable Ribonucleoproteins and Its Mapping With Grad-Seq and Related Approaches

Gerovac M, Vogel J, Smirnov A (2021)

Frontiers in Molecular Biosciences 8: 661448DOI: 10.3389/fmolb.2021.661448

In vivo targets of Salmonella FinO include a FinP-like small RNA controlling copy number of a cohabitating plasmid

El Mouali Y, Gerovac M, Mineikaite R, Vogel J (2021)

Nucleic Acids Research 49 (9): 5319-5335DOI: 10.1093/nar/gkab281

Analysis of the RNA and Protein Complexome by Grad-seq

Hör J, Vogel J (2021)

Methods in Molecular Biology 2300: 183-201DOI: 10.1007/978-1-0716-1386-3_16

Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics

Popella L, Jung J, Popova K, Ðurica-Mitic S, Barquist L, Vogel J (2021)

Nucleic Acids Research 49 (8): 4705-4724DOI: 10.1093/nar/gkab242

A Grad-seq View of RNA and Protein Complexes in Pseudomonas aeruginosa under Standard and Bacteriophage Predation Conditions

Gerovac M, Wicke L, Chihara K, Schneider C, Lavigne R, Vogel J (2021)

mBio 12 (1): 03454-20DOI: 10.1128/mBio.03454-20

MAPS integrates regulation of actin-targeting effector SteC into the virulence control network of Salmonella small RNA PinT

Correia Santos S, Bischler T, Westermann AJ, Vogel J (2021)

Cell Reports 34 (5): 108722DOI: 10.1016/j.celrep.2021.108722

Cross-species RNA-seq for deciphering host–microbe interactions

Westermann AJ, Vogel J (2021)

Nature Reviews Genetics 22 (6): 361DOI: 10.1038/s41576-021-00326-y

A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity

Bernhardt L, Dittrich M, El-Merahbi R, Saliba A, Müller T, Sumara G, Vogel J, Nichols-Burns S, Mitchell M, Haaf T, El Hajj N (2021)

Scientific Reports 11: 1979DOI: 10.1038/s41598-021-81226-3

Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia

Chumduri C, Gurumurthy RK, Berger H, Dietrich O, Kumar N, Koster S, Brinkmann V, Hoffmann K, Drabkina M, Arampatzi P, …, Saliba A, Meyer TF (2021)

Nature Cell Biology 23 (2): 184DOI: 10.1038/s41556-020-00619-0

Introducing differential RNA-seq mapping to track the early infection phase for Pseudomonas phage ɸKZ

Wicke L, Ponath F, Coppens L, Gerovac M, Lavigne R, Vogel J (2021)

RNA Biology 18 (8): 1099-1110DOI: 10.1080/15476286.2020.1827785