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Jun Prof Franziska Faber

About

Franziska Faber studied biology at the Martin-Luther University (Halle/Saale, Germany). Her doctoral work at the Robert Koch Institute (Wernigerode, Germany) introduced her to the field of enteric bacterial infections. In 2011, she started her postdoctoral work in the lab of Andreas Bäumler at the University of California (Davis, USA). Here, she studied the mechanisms by which antibiotic treatment lowers “colonization resistance” against the enteric pathogen Salmonella  enterica. More specifically, she explored how inflammation-associated changes in intestinal nutrients contribute to intestinal colonization of S. enterica. In 2018, she joined the Center for Infectious Disease Research (ZINF) in Würzburg as a Young Investigator to study the previously unexplored RNA biology of the intestinal pathogen Clostridioides difficile. Since 2021, she is a Junior Professor at the Institute of Molecular Infection Biology (IMIB) and leads the ROSE group located at the Julius-Maximilians-University Würzburg and associated with HIRI.


2023

Durchfallerreger und die Homöostase der Mikrobiota

Winter S, Faber F, Bäumler A (2023)

BIOspektrum 29 (2): 127-129DOI: 10.1007/s12268-023-1901-3

A network of small RNAs regulates sporulation initiation in C difficile

Fuchs M, Lamm-Schmidt V, Lence T, Sulzer J, Bublitz A, Wackenreuter J, Gerovac M, Strowig T, Faber F (2023)

EMBO Journal (Online ahead of print)DOI: 10.15252/embj.2022112858

2021

Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production

Lamm-Schmidt V, Fuchs M, Sulzer J, Gerovac M, Hör J, Dersch P, Vogel J, Faber F (2021)

microLife 2: 3704DOI: 10.1093/femsml/uqab004

Malaria parasite infection compromises colonization resistance to an enteric pathogen by reducing gastric acidity

Walker GT, Yang G, Tsai JY, Rodriguez JL, English BC, Faber F, Souvannaseng L, Butler BP, Tsolis RM (2021)

Science Advances 7 (27): 6232DOI: 10.1126/sciadv.abd6232

The metabolic footprint of Clostridia and Erysipelotrichia reveals their role in depleting sugar alcohols in the cecum

Tiffany CR, Lee JY, Rogers AWL, Olsan EE, Morales P, Faber F, Bäumler AJ (2021)

Microbiome 9 (1): 174DOI: 10.1186/s40168-021-01123-9

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium

Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J, Faber F (2021)

PNAS 118 (25): 2103579DOI: 10.1073/pnas.2103579118

RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum

Ponath F, Tawk C, Zhu Y, Barquist L, Faber F, Vogel J (2021)

Nature Microbiology 6 (8): 1007-1020DOI: 10.1038/s41564-021-00927-7

2020

Antibacterial Anacardic Acid Derivatives

Saedtler M, Förtig N, Ohlsen K, Faber F, Masota N, Kowalick K, Holzgrabe U, Meinel L (2020)

ACS Infectious Diseases 6 (7): 1674-1685DOI: 10.1021/acsinfecdis.9b00378

2019

Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition

Litvak Y, Mon KKZ, Nguyen H, Chanthavixay G, Liou M, Velazquez EM, Kutter L, Alcantara MA, Byndloss MX, Tiffany CR, …, Zhou H, Bäumler AJ (2019)

Cell Host & Microbe 25 (1): 128-139DOI: 10.1016/j.chom.2018.12.003

Social behaviour and making attachments: a report from the fifth 'Young Microbiologists Symposium on Microbe Signalling, Organisation and Pathogenesis'

An SQ, Ding YC, Faber F, Hobley L, Sá-Pessoa J (2019)

Microbiology 165 (2): 138-145DOI: 10.1099/mic.0.000746

Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection

Velazquez EM, Nguyen H, Heasley KT, Saechao CH, Gil LM, Rogers AWL, Miller BM, Rolston MR, Lopez CA, Litvak Y, …, Byndloss AJ, Bäumler AJ (2019)

Nature Microbiology 4 (6): 1057-1064DOI: 10.1038/s41564-019-0407-8

2018

Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease

Bronner DN, Faber F, Olsan EE, Byndloss MX, Sayed NA, Xu G, Yoo W, Kim D, Ryu S, Lebrilla CB, Bäumler AJ (2018)

Cell Host & Microbe 23 (2): 266-273DOI: 10.1016/j.chom.2018.01.004

2017

Colonization resistance: The deconvolution of a complex trait

Olsan EE, Byndloss MX, Faber F, Rivera-Chávez F, Tsolis RM, Bäumler AJ (2017)

The Journal of Biological Chemistry 292 (21): 8577-8581DOI: 10.1074/jbc.R116.752295

A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid

Elfenbein JR, Knodler LA, Schaeffer AR, Faber F, Bäumler AJ, Andrews-Polymenis HL (2017)

Frontiers in Cellular and Infection Microbiology 7: 69DOI: 10.3389/fcimb.2017.00069

Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

Faber F, Thiennimitr P, Spiga L, Byndloss MX, Litvak Y, Lawhon S, Andrews-Polymenis HL, Winter SE, Bäumler AJ (2017)

PLOS Pathogens 13 (1): 1006129DOI: 10.1371/journal.ppat.1006129

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, …, Lebrilla CB, Bäumler AJ (2017)

Science 357 (6351): 570-575DOI: 10.1126/science.aam9949

2016

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

Rivera-Chávez F, Zhang LF, Faber F, Lopez CA, Byndloss MX, Olsan EE, Xu G, Velazquez EM, Lebrilla CB, Winter SE, Bäumler AJ (2016)

Cell Host & Microbe 19 (4): 443-54DOI: 10.1016/j.chom.2016.03.004

Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion

Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ (2016)

Nature 534 (7609): 697-9DOI: 10.1038/nature18597

2015

Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection

Mooney JP, Lokken KL, Byndloss MX, George MD, Velazquez EM, Faber F, Butler BP, Walker GT, Ali MM, Potts R, …, Luckhart S, Tsolis RM (2015)

Scientific Reports 5: 14603DOI: 10.1038/srep14603

2014

The impact of intestinal inflammation on the nutritional environment of the gut microbiota

Faber F, Bäumler AJ (2014)

Immunology Letters 162 (2 Pt A): 48-53DOI: 10.1016/j.imlet.2014.04.014

Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation

Winter SE, Winter MG, Poon V, Keestra AM, Sterzenbach T, Faber F, Costa LF, Cassou F, Costa EA, Alves GE, …, Santos RL, Bäumler AJ (2014)

PLOS Pathogens 10 (7): 1004207DOI: 10.1371/journal.ppat.1004207

2012

Surface-associated motility, a common trait of clinical isolates of Acinetobacter baumannii, depends on 1,3-diaminopropane

Skiebe E, de Berardinis V, Morczinek P, Kerrinnes T, Faber F, Lepka D, Hammer B, Zimmermann O, Ziesing S, Wichelhaus TA, …, Pfeifer Y, Wilharm G (2012)

International Journal of Medical Microbiology 302 (3): 117-28DOI: 10.1016/j.ijmm.2012.03.003

2010

A simple and rapid method of bacterial transformation

Wilharm G, Lepka D, Faber F, Hofmann J, Kerrinnes T, Skiebe E (2010)

Journal of Microbiological Methods 80 (2): 215-6DOI: 10.1016/j.mimet.2009.12.002

Orbus hercynius gen. nov., sp. nov., isolated from faeces of wild boar, is most closely related to members of the orders 'Enterobacteriales' and Pasteurellales

Volkmann M, Skiebe E, Kerrinnes T, Faber F, Lepka D, Pfeifer Y, Holland G, Bannert N, Wilharm G (2010)

International Journal of Systematic and Evolutionary Microbiology 60 (Pt 11): 2601-2605DOI: 10.1099/ijs.0.019026-0

2009

CsrA and CsrB are required for the post-transcriptional control of the virulence-associated effector protein AvrA of Salmonella enterica

Kerrinnes T, Zelas ZB, Streckel W, Faber F, Tietze E, Tschäpe H, Yaron S (2009)

International Journal of Medical Microbiology 299 (5): 333-41DOI: 10.1016/j.ijmm.2008.09.001

2007

Influence of poly(L-lysine) on the structure of dipalmitoylphosphatidylglycerol/water dispersions studied by X-ray scattering

Förster G, Schwieger C, Faber F, Weber T, Blume A (2007)

European Biophysics Journal 36 (4-5): 425-35DOI: 10.1007/s00249-006-0087-1

2006

Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice

Faber F, Gembardt F, Sun X, Mizutani S, Siems WE, Walther T (2006)

Regulatory Peptides 136 (1-3): 130-7DOI: 10.1016/j.regpep.2006.06.001