Jun Prof Mathias Munschauer
About
Mathias Munschauer started working with RNA and RNA-binding proteins as an undergraduate student in the lab of Thomas Tuschl at Rockefeller University in New York. He completed his thesis research on the RNA-binding protein FMRP under the supervision of Thomas Tuschl. He then joined an international PhD exchange program jointly operated by the Max-Delbrück Center for Molecular Medicine in Berlin (working with Markus Landthaler) and at New York University (working with Christine Vogel). In the Landthaler lab, Mathias Munschauer pioneered technologies to capture the mRNA-bound proteome and display its global protein occupancy pattern on protein coding transcripts for the first time. For his postdoctoral research, he joined the lab of Eric Lander at the Broad Institute of MIT and Harvard, where he identified a novel lncRNA-dependent topoisomerase complex and dissected how the lncRNA NORAD contributes to genome stability. He joined the HIRI in July 2019 as head of his independent Helmholtz Young Investigator Group.
2023
Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency
Jürgens DC, Deßloch L, Porras-Gonzalez D, Winkeljann J, Zielinski S, Munschauer M, Hörner AL, Burgstaller G, Winkeljann B, Merkel OM (2023)
OpenNano 12 (1): 100161DOI: 10.1016/j.onano.2023.100161
2022
Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Ludwig LS, Lareau CA, Bao EL, Liu N, Utsugisawa T, Tseng AM, Myers SA, Verboon JM, Ulirsch JC, Luo W, …, Kanno H, Sankaran VG (2022)
Blood 139 (16): 2534-2546DOI: 10.1182/blood.2021013753
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, …, Stark K, Nicolai L (2022)
Nature Communications 13 (1): 1018DOI: 10.1038/s41467-022-28508-0
2021
Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen
Schmidt N, Munschauer M (2021)
BIOspektrum 27 (4): 376-379DOI: 10.1007/s12268-021-1587-3
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts
Gonzalez-Perez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, …, Erhard F, Brinkmann MM (2021)
mBio 12 (3): 02683-20DOI: 10.1128/mBio.02683-20
2020
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation
Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, …, Lander ES, Sankaran VG (2020)
Nature Genetics 52 (2): 138-145DOI: 10.1038/s41588-019-0568-7
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer
Gandhi M, Groß M, Holler JM, Coggins SA, Patil N, Leupold JH, Munschauer M, Schenone M, Hartigan CR, Allgayer H, Kim B, Diederichs S (2020)
Nature Communications 11: 3214DOI: 10.1038/s41467-020-17007-9
The SARS-CoV-2 RNA-protein interactome in infected human cells
Schmidt N, Lareau CA, Keshishian H, Ganskih S, Schneider C, Hennig T, Melanson R, Werner S, Wei Y, Zimmer M, …, Bodem J, Munschauer M (2020)
Nature Microbiology 6 (3): 339-353DOI: 10.1038/s41564-020-00846-z
2019
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat
Labi V, Peng S, Klironomos F, Munschauer M, Kastelic N, Chakraborty T, Schoeler K, Derudder E, Martella M, Mastrobuoni G, …, Rajewsky N, Rajewsky K (2019)
Genes & Development 33 (23-24): 1673-1687DOI: 10.1101/gad.330134.119
2018
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, …, Carr SA, Sankaran VG (2018)
Cell 173 (1): 90-103DOI: 10.1016/j.cell.2018.02.036
New insights into the cellular temporal response to proteostatic stress
Rendleman J, Cheng Z, Maity S, Kastelic N, Munschauer M, Allgoewer K, Teo G, Zhang YB, Lei A, Parker B, …, Choi H, Vogel C (2018)
eLife 7: 39054DOI: 10.7554/eLife.39054
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
Munschauer M, Nguyen CT, Sirokman K, Hartigan CR, Hogstrom L, Engreitz JM, Ulirsch JC, Fulco CP, Subramanian V, Chen J, …, Carr SA, Lander ES (2018)
Nature 561 (7721): 132-136DOI: 10.1038/s41586-018-0453-z
Nuclear lncRNA stabilization in the host response to bacterial infection
Munschauer M, Vogel J (2018)
The EMBO Journal 37 (13): 99875DOI: 10.15252/embj.201899875
2017
Developmentally-faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice
Fiorini C, Abdulhay NJ, McFarland SK, Munschauer M, Ulirsch JC, Chiarle R, Sankaran VG (2017)
American Journal of Hematology 92 (9): 513-DOI: 10.1002/ajh.24805
2016
Systematic mapping of functional enhancer-promoter connections with CRISPR interference
Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES, Engreitz JM (2016)
Science 354 (6313): 769-773DOI: 10.1126/science.aag2445
2015
Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins
Bish R, Cuevas-Polo N, Cheng Z, Hambardzumyan D, Munschauer M, Landthaler M, Vogel C (2015)
Biomolecules 5 (3): 1441-66DOI: 10.3390/biom5031441
2014
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs
Gregersen LH, Schueler M, Munschauer M, Mastrobuoni G, Chen W, Kempa S, Dieterich C, Landthaler M (2014)
Molecular Cell 54 (4): 573-85DOI: 10.1016/j.molcel.2014.03.017
Differential protein occupancy profiling of the mRNA transcriptome
Schueler M, Munschauer M, Gregersen LH, Finzel A, Loewer A, Chen W, Landthaler M, Dieterich C (2014)
Genome Biology 15 (1): 15DOI: 10.1186/gb-2014-15-1-r15
High-resolution profiling of protein occupancy on polyadenylated RNA transcripts
Munschauer M, Schueler M, Dieterich C, Landthaler M (2014)
Methods 65 (3): 302-9DOI: 10.1016/j.ymeth.2013.09.017
2013
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, …, Le Noble F, Rajewsky N (2013)
Nature 495 (7441): 333-8DOI: 10.1038/nature11928
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
Graf R, Munschauer M, Mastrobuoni G, Mayr F, Heinemann U, Kempa S, Rajewsky N, Landthaler M (2013)
RNA Biology 10 (7): 1146-59DOI: 10.4161/rna.25194
2012
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, …, Dieterich C, Landthaler M (2012)
Molecular Cell 46 (5): 674-90DOI: 10.1016/j.molcel.2012.05.021
FMRP targets distinct mRNA sequence elements to regulate protein expression
Ascano M, Mukherjee N, Bandaru P, Miller JB, Nusbaum JD, Corcoran DL, Langlois C, Munschauer M, Dewell S, Hafner M, …, Ohler U, Tuschl T (2012)
Nature 492 (7429): 382-6DOI: 10.1038/nature11737
2010
PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp A, Munschauer M, …, Zavolan M, Tuschl T (2010)
Journal of Visualized Experiments (41): 2034DOI: 10.3791/2034
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp A, Munschauer M, …, Zavolan M, Tuschl T (2010)
Cell 141 (1): 129-41DOI: 10.1016/j.cell.2010.03.009