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Jun Prof Redmond Smyth

About

Redmond Smyth carried out his undergraduate degree in Natural Sciences at the University of Cambridge (UK), specializing in Virology and Immunology. He then moved to the Burnet Institute, Melbourne (Australia) for his PhD, where he investigated the mechanisms of HIV-1 genetic diversity in its natural target cells. His PhD research pointed to the importance of RNA structure in regulating viral infection processes, which is why he then moved to Strasbourg (France) for his post-doctoral research to train as an RNA biochemist. Here, he worked on understanding the mechanisms leading to the incorporation of the HIV-1 genomic RNA into viral particles. In 2015, he was recruited to the CNRS as a chargé de recherché (CR2), and in 2018, with support from the Helmholtz Association, he started his own research group at the Helmholtz Institute for RNA-based Infection Research (HIRI).


2023

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, …, Erhard F, Munschauer M (2023)

Cell 186 (22): 4834-4850.e23DOI: 10.1016/j.cell.2023.09.002

Advanced fluorescence microscopy in respiratory virus cell biology

Xie E, Ahmad S, Smyth RP, Sieben C (2023)

Advances in Virus Research 116: 123-172DOI: 10.1016/bs.aivir.2023.05.002

Sequential disruption of SPLASH-identified vRNA-vRNA interactions challenges their role in influenza A virus genome packaging

Jakob C, Lovate GL, Desirò D, Gießler L, Smyth RP, Marquet R, Lamkiewicz K, Marz M, Schwemmle M, Bolte H (2023)

Nucleic Acids Research 51 (12): 6479-6494DOI: 10.1093/nar/gkad442

Nano-DMS-MaP allows isoform-specific RNA structure determination

Bohn P, Gribling-Burrer AS, Ambi UB, Smyth RP (2023)

Nature Methods 20 (6): 849-859DOI: 10.1038/s41592-023-01862-7

Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Pekarek L, Zimmer MM, Gribling-Burrer AS, Buck S, Smyth RP, Caliskan N (2023)

Nucleic Acids Research 51 (2): 728–743DOI: 10.1093/nar/gkac1184

2022

Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging

Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP (2022)

Nature Structural & Molecular Biology 29 (4): 306-319DOI: 10.1038/s41594-022-00746-2

2021

RNA Structures and Their Role in Selective Genome Packaging

Ye L, Ambi UB, Olguin-Nava M, Gribling-Burrer AS, Ahmad S, Bohn P, Weber MM, Smyth RP (2021)

Viruses 13 (9): 1788DOI: 10.3390/v13091788

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Zimmer MM, Kibe A, Rand U, Pekarek L, Ye L, Buck S, Smyth RP, Cicin-Sain L, Caliskan N (2021)

Nature Communications 12 (1): 7193DOI: 10.1038/s41467-021-27431-0

2019

The evolution of RNA structural probing methods: From gels to next-generation sequencing

Mailler E, Paillart J, Marquet R, Smyth RP, Vivet-Boudou V (2019)

Wiley Interdisciplinary Reviews: RNA 10 (2): e1518DOI: 10.1002/wrna.1518

2018

RNA Structure - A Neglected Puppet Master for the Evolution of Virus and Host Immunity

Smyth RP, Negroni M, Lever AM, Mak J, Kenyon JC (2018)

Frontiers in Immunology 9: 2097DOI: 10.3389/fimmu.2018.02097

Structural and Functional Motifs in Influenza Virus RNAs

Ferhadian D, Contrant M, Printz-Schweigert A, Smyth RP, Paillart J, Marquet R (2018)

Frontiers in Microbiology 9: 559DOI: 10.3389/fmicb.2018.00559

In cell mutational interference mapping experiment (in cell MIME) identifies the 5' polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging

Smyth RP, Smith MR, Jousset A, Despons L, Laumond G, Decoville T, Cattenoz P, Moog C, Jossinet F, Mougel M, …, Kleist M, Marquet R (2018)

Nucleic Acids Research 46 (9): e57DOI: 10.1093/nar/gky152

2017

HIV-1 Pr55Gag binds genomic and spliced RNAs with different affinity and stoichiometry

Bernacchi S, Abd El-Wahab EW, Dubois N, Hijnen M, Smyth RP, Mak J, Marquet R, Paillart J (2017)

RNA Biology 14 (1): 90-103DOI: 10.1080/15476286.2016.1256533

2016

HIV-1 Mutation and Recombination Rates Are Different in Macrophages and T-cells

Cromer D, Schlub TE, Smyth RP, Grimm AJ, Chopra A, Mallal S, Davenport MP, Mak J (2016)

Viruses 8 (4): 118DOI: 10.3390/v8040118

A step forward understanding HIV-1 diversity

Smyth RP, Negroni M (2016)

Retrovirology 13: 27DOI: 10.1186/s12977-016-0259-8

The Life-Cycle of the HIV-1 Gag-RNA Complex

Mailler E, Bernacchi S, Marquet R, Paillart J, Vivet-Boudou V, Smyth RP (2016)

Viruses 8 (9): E248DOI: 10.3390/v8090248

MIMEAnTo: profiling functional RNA in mutational interference mapping experiments

Smith MR, Smyth RP, Marquet R, Kleist M (2016)

Bioinformatics 32 (21): 3369-3370DOI: 10.1093/bioinformatics/btw479

2015

Evaluation of anti-HIV-1 mutagenic nucleoside analogues

Vivet-Boudou V, Isel C, El Safadi Y, Smyth RP, Laumond G, Moog C, Paillart J, Marquet R (2015)

The Journal of Biological Chemistry 290 (1): 371-83DOI: 10.1074/jbc.M114.616383

Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection

Hawkes D, Jones KL, Smyth RP, Pereira CF, Bittman R, Jaworowski A, Mak J (2015)

Virus Research 210: 18-21DOI: 10.1016/j.virusres.2015.06.023

Mutational interference mapping experiment (MIME) for studying RNA structure and function

Smyth RP, Despons L, Huili G, Bernacchi S, Hijnen M, Mak J, Jossinet F, Weixi L, Paillart J, Kleist M, Marquet R (2015)

Nature Methods 12 (9): 866-72DOI: 10.1038/nmeth.3490

2014

Identifying recombination hot spots in the HIV-1 genome

Smyth RP, Schlub TE, Grimm AJ, Waugh C, Ellenberg P, Chopra A, Mallal S, Cromer D, Mak J, Davenport MP (2014)

Journal of Virology 88 (5): 2891-902DOI: 10.1128/JVI.03014-13

Fifteen to twenty percent of HIV substitution mutations are associated with recombination

Schlub TE, Grimm AJ, Smyth RP, Cromer D, Chopra A, Mallal S, Venturi V, Waugh C, Mak J, Davenport MP (2014)

Journal of Virology 88 (7): 3837-49DOI: 10.1128/JVI.03136-13

Specific recognition of the HIV-1 genomic RNA by the Gag precursor

Abd El-Wahab EW, Smyth RP, Mailler E, Bernacchi S, Vivet-Boudou V, Hijnen M, Jossinet F, Mak J, Paillart J, Marquet R (2014)

Nature Communications 5: 4304DOI: 10.1038/ncomms5304

2013

Improved quantification of HIV-1-infected CD4+ T cells using an optimised method of intracellular HIV-1 gag p24 antigen detection

Yang H, Yorke E, Hancock G, Clutton G, Sande N, Angus B, Smyth RP, Mak J, Dorrell L (2013)

Journal of Immunological Methods 391 (1-2): 174-8DOI: 10.1016/j.jim.2013.03.001

Intracellular Dynamics of HIV Infection

Petravic J, Ellenberg P, Chan M, Paukovics G, Smyth RP, Mak J, Davenport MP (2013)

Journal of Virology 88 (2): 1113-24DOI: 10.1128/JVI.02038-13

A functional sequence-specific interaction between influenza A virus genomic RNA segments

Gavazzi C, Yver M, Isel C, Smyth RP, Rosa-Calatrava M, Lina B, Moulès V, Marquet R (2013)

PNAS 110 (41): 16604-9DOI: 10.1073/pnas.1314419110

2012

The Origin of Genetic Diversity in HIV-1

Smyth RP, Davenport MP, Mak J (2012)

Virus Research 169 (2): 415-29DOI: 10.1016/j.virusres.2012.06.015

2011

8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription

Vivet-Boudou V, Isel C, Sleiman M, Smyth RP, Ben Gaied N, Barhoum P, Laumond G, Bec G, Götte M, Mak J, …, Burger A, Marquet R (2011)

PLOS One 6 (11): e27456DOI: 10.1371/journal.pone.0027456

Early events of HIV-1 infection: can signaling be the next therapeutic target?

Jones KL, Smyth RP, Pereira CF, Cameron PU, Lewin SR, Jaworowski A, Mak J (2011)

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 6 (2): 269-83DOI: 10.1007/s11481-011-9268-5

Labeling of multiple HIV-1 proteins with the biarsenical-tetracysteine system

Pereira CF, Ellenberg PC, Jones KL, Fernandez TL, Smyth RP, Hawkes DJ, Hijnen M, Vivet-Boudou V, Marquet R, Johnson I, Mak J (2011)

PLOS One 6 (2): e17016DOI: 10.1371/journal.pone.0017016

2010

Accurately measuring recombination between closely related HIV-1 genomes

Schlub TE, Smyth RP, Grimm AJ, Mak J, Davenport MP (2010)

PLOS Computational Biology 6 (4): e1000766DOI: 10.1371/journal.pcbi.1000766

Reducing chimera formation during PCR amplification to ensure accurate genotyping

Smyth RP, Schlub TE, Grimm A, Venturi V, Chopra A, Mallal S, Davenport MP, Mak J (2010)

Gene 469 (1-2): 45-51DOI: 10.1016/j.gene.2010.08.009

2009

The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA

Keating CP, Hill MK, Hawkes DJ, Smyth RP, Isel C, Le S, Palmenberg AC, Marshall JA, Marquet R, Nabel GJ, Mak J (2009)

Nucleic Acids Research 37 (3): 945-56DOI: 10.1093/nar/gkn1015