Attention deficit hyperactivity disorder, or ADHD, is an early-onset, commonly persistent neurodevelopmental condition characterized by inattention, impulsivity, and hyperactivity. ADHD shows differing trajectories but persists into adulthood in at least half of affected children. However, the causes and course of the disorder are not yet fully understood. There are also large variabilities in treatment responses to first line.
In her project at the Single-Cell Center Würzburg, Sarah Kittel-Schneider, formerly from the University Hospital Würzburg (UKW), currently University College Cork, Ireland, wants to investigate the development of ADHD at the level of single cells. Together with Rhiannon McNeill and Franziska Radtke from UKW, she has developed a neuronal model for this purpose. With the help of this model, the team, which is completed by Emmanuel Saliba from the Helmholtz Institute Würzburg, Florian Erhard from the University of Regensburg, and Andreas Chiocchetti from the University Hospital in Frankfurt, now wants to determine cellular differences between healthy controls and ADHD patients. The findings could lead to better treatment options.