Dr Antoine-Emmanuel Saliba


Antoine-Emmanuel Saliba studied biochemical engineering at INSA Toulouse (France) and received his PhD in the research group of Jean-Louis Viovy at the Institut Curie (Paris, France). During this time, he developed microfluid-based systems for sorting and analysing rare subpopulations of cancer cells. He then worked as an EIPOD fellow at the European Molecular Biology Laboratory (Heidelberg, Germany) and was involved in the development of innovative systems biology methods for the analysis of protein-lipid interactions. He then joined Jörg Vogel's laboratory in Würzburg as a senior postdoctoral fellow and established single-cell RNA-sequencing to track the fate of individual cells during an infection with Salmonella enterica. Since 2017 he has led the Single-cell Analysis group at HIRI.


scSLAM-seq reveals core features of transcription dynamics in single cells

Erhard F, Baptista M, Krammer T, Hennig T, Lange M, Arampatzi P, Jürges C, Theis F, Saliba A, Dölken L (2019)

Nature, 571 (7765): 419-423DOI: 10.1038/s41586-019-1369-y


Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh H, Kobiyama K, Hamers A, Cochain C, Vafadarnejad E, Saliba A, …, Ley K, Wolf D (2018)

Circ Res, 122 (12): 1675-1688DOI: 10.1161/CIRCRESAHA.117.312513

Salmonella persisters undermine host immune defenses during antibiotic treatment

Stapels D, Hill P, Westermann A, Fisher R, Thurston T, Saliba A, Blommestein I, Vogel J, Helaine S (2018)

Science, 362 (6419): 1156-1160DOI: 10.1126/science.aat7148

Genome organization and DNA accessibility control antigenic variation in trypanosomes

Müller L, Cosentino R, Förstner K, Guizetti J, Wedel C, Kaplan N, Janzen C, Arampatzi P, Vogel J, Steinbiss S, …, Sebra R, Siegel T (2018)

Nature, 563 (7729): 121-125DOI: 10.1038/s41586-018-0619-8

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry G, Vafadarnejad E, Floess S, Arampatzi P, Buettner M, …, Saliba A, Huehn J (2018)

Nat Commun, 9 (1)DOI: 10.1038/s41467-018-06423-7

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba A, Zernecke A (2018)

Circ Res, 122 (12): 1661-1674DOI: 10.1161/CIRCRESAHA.117.312509


Einzelzell-RNA-Sequenzierung beleuchtet den Infektionsprozess

Saliba A, Westermann A, Vogel J (2017)

Biospektrum, 23 (5): 525-528DOI: 10.1007/s12268-017-0836-y

New RNA-seq approaches for the study of bacterial pathogens

Saliba A, C Santos S, Vogel J (2017)

Curr Opin Microbiol, 35: 78-87DOI: 10.1016/j.mib.2017.01.001


Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella

Saliba A, Li L, Westermann A, Appenzeller S, Stapels D, Schulte L, Helaine S, Vogel J (2016)

Nat Microbiol, 2DOI: 10.1038/nmicrobiol.2016.206

A protocol for the systematic and quantitative measurement of protein-lipid interactions using the liposome-microarray-based assay

Saliba A, Vonkova I, Deghou S, Ceschia S, Tischer C, Kugler K, Bork P, Ellenberg J, Gavin A (2016)

Nat Protoc, 11 (6): 1021-38DOI: 10.1038/nprot.2016.059


Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains

Vonkova I, Saliba A, Deghou S, Anand K, Ceschia S, Doerks T, Galih A, Kugler K, Maeda K, Rybin V, …, Bork P, Gavin A (2015)

Cell Rep, 12 (9): 1519-30DOI: 10.1016/j.celrep.2015.07.054

The systematic analysis of protein-lipid interactions comes of age

Saliba A, Vonkova I, Gavin A (2015)

Nat Rev Mol Cell Biol, 16 (12): 753-61DOI: 10.1038/nrm4080


Single-cell RNA-seq: advances and future challenges

Saliba A, Westermann A, Gorski S, Vogel J (2014)

Nucleic Acids Res, 42 (14): 8845-60DOI: 10.1093/nar/gku555

A quantitative liposome microarray to systematically characterize protein-lipid interactions

Saliba A, Vonkova I, Ceschia S, Findlay G, Maeda K, Tischer C, Deghou S, van Noort V, Bork P, Pawson T, Ellenberg J, Gavin A (2014)

Nat Methods, 11 (1): 47-50DOI: 10.1038/nmeth.2734


Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays

Saliba A, Saias L, Psychari E, Minc N, Simon D, Bidard F, Mathiot C, Pierga J, Fraisier V, Salamero J, …, Malaquin L, Viovy J (2010)

Proc Natl Acad Sci U S A, 107 (33): 14524-9DOI: 10.1073/pnas.1001515107


Cellules tumorales circulantes et cancer du sein : méthodes de détection et résultats cliniques

Bidard F, Saliba A, Saias L, Degeorges A, Cremoux P, Viovy J, Vincent-Salomon A, Mathiot C, Pierga J, Gramont A (2009)

Bull Cancer, 96 (1): 73-86DOI: 10.1684/bdc.2008.0797

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