Dr Mathias Munschauer


Mathias Munschauer started working with RNA and RNA-binding proteins as an undergraduate student in the lab of Thomas Tuschl at Rockefeller University in New York. He completed his thesis research on the RNA-binding protein FMRP under the supervision of Thomas Tuschl. He then joined an international PhD exchange program jointly operated by the Max-Delbrück Center for Molecular Medicine in Berlin (working with Markus Landthaler) and at New York University (working with Christine Vogel). In the Landthaler lab, Mathias Munschauer pioneered technologies to capture the mRNA-bound proteome and display its global protein occupancy pattern on protein coding transcripts for the first time. For his postdoctoral research, he joined the lab of Eric Lander at the Broad Institute of MIT and Harvard, where he identified a novel lncRNA-dependent topoisomerase complex and dissected how the lncRNA NORAD contributes to genome stability. Following his 5-year tenure in the Lander lab, he will become a Helmholtz Young Investigator and join HIRI in July 2019 to start his independent research group.


New insights into the cellular temporal response to proteostatic stress

Rendleman J, Cheng Z, Maity S, Kastelic N, Munschauer M, Allgoewer K, Teo G, Zhang Y, Lei A, Parker B, …, Choi H, Vogel C (2018)

Elife, 7: 39054DOI: 10.7554/eLife.39054

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

Munschauer M, Nguyen C, Sirokman K, Hartigan C, Hogstrom L, Engreitz J, Ulirsch J, Fulco C, Subramanian V, Chen J, …, Carr S, Lander E (2018)

Nature, 561 (7721): 132-136DOI: 10.1038/s41586-018-0453-z

Nuclear lncRNA stabilization in the host response to bacterial infection

Munschauer M, Vogel J (2018)

EMBO J, 37 (13): 99875DOI: 10.15252/embj.201899875

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

Khajuria R, Munschauer M, Ulirsch J, Fiorini C, Ludwig L, McFarland S, Abdulhay N, Specht H, Keshishian H, Mani D, …, Carr S, Sankaran V (2018)

Cell, 173 (1): 90-103DOI: 10.1016/j.cell.2018.02.036


Developmentally-faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice

Fiorini C, Abdulhay N, McFarland S, Munschauer M, Ulirsch J, Chiarle R, Sankaran V (2017)

Am J Hematol, 92 (9): 513-DOI: 10.1002/ajh.24805


Systematic mapping of functional enhancer-promoter connections with CRISPR interference

Fulco C, Munschauer M, Anyoha R, Munson G, Grossman S, Perez E, Kane M, Cleary B, Lander E, Engreitz J (2016)

Science, 354 (6313): 769-773DOI: 10.1126/science.aag2445


Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins

Bish R, Cuevas-Polo N, Cheng Z, Hambardzumyan D, Munschauer M, Landthaler M, Vogel C (2015)

Biomolecules, 5 (3): 1441-66DOI: 10.3390/biom5031441


Differential protein occupancy profiling of the mRNA transcriptome

Schueler M, Munschauer M, Gregersen L, Finzel A, Loewer A, Chen W, Landthaler M, Dieterich C (2014)

Genome Biol, 15 (1): 15DOI: 10.1186/gb-2014-15-1-r15

High-resolution profiling of protein occupancy on polyadenylated RNA transcripts

Munschauer M, Schueler M, Dieterich C, Landthaler M (2014)

Methods (San Diego, Calif.), 65 (3): 302-9DOI: 10.1016/j.ymeth.2013.09.017

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs

Gregersen L, Schueler M, Munschauer M, Mastrobuoni G, Chen W, Kempa S, Dieterich C, Landthaler M (2014)

Mol Cell, 54 (4): 573-85DOI: 10.1016/j.molcel.2014.03.017


Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation

Graf R, Munschauer M, Mastrobuoni G, Mayr F, Heinemann U, Kempa S, Rajewsky N, Landthaler M (2013)

RNA Biol, 10 (7): 1146-59DOI: 10.4161/rna.25194

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak S, Gregersen L, Munschauer M, …, Le Noble F, Rajewsky N (2013)

Nature, 495 (7441): 333-8DOI: 10.1038/nature11928


The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

Baltz A, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, …, Dieterich C, Landthaler M (2012)

Mol Cell, 46 (5): 674-90DOI: 10.1016/j.molcel.2012.05.021

FMRP targets distinct mRNA sequence elements to regulate protein expression

Ascano M, Mukherjee N, Bandaru P, Miller J, Nusbaum J, Corcoran D, Langlois C, Munschauer M, Dewell S, Hafner M, …, Ohler U, Tuschl T (2012)

Nature, 492 (7429): 382-6DOI: 10.1038/nature11737


PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins

Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp A, Munschauer M, …, Zavolan M, Tuschl T (2010)

J Vis Exp (41): 2034DOI: 10.3791/2034

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp A, Munschauer M, …, Zavolan M, Tuschl T (2010)

Cell, 141 (1): 129-41DOI: 10.1016/j.cell.2010.03.009

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