Jun Prof Redmond Smyth
About
Redmond Smyth carried out his undergraduate degree in Natural Sciences at the University of Cambridge (UK), specializing in Virology and Immunology. He then moved to the Burnet Institute, Melbourne (Australia) for his PhD, where he investigated the mechanisms of HIV-1 genetic diversity in its natural target cells. His PhD research pointed to the importance of RNA structure in regulating viral infection processes, which is why he then moved to Strasbourg (France) for his post-doctoral research to train as an RNA biochemist. Here, he worked on understanding the mechanisms leading to the incorporation of the HIV-1 genomic RNA into viral particles. In 2015, he was recruited to the CNRS as a chargé de recherché (CR2), and in 2018, with support from the Helmholtz Association, he started his own research group at the Helmholtz Institute for RNA-based Infection Research (HIRI).
2023
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, …, Erhard F, Munschauer M (2023)
Cell 186 (22): 4834-4850.e23DOI: 10.1016/j.cell.2023.09.002
Advanced fluorescence microscopy in respiratory virus cell biology
Xie E, Ahmad S, Smyth RP, Sieben C (2023)
Advances in Virus Research 116: 123-172DOI: 10.1016/bs.aivir.2023.05.002
Sequential disruption of SPLASH-identified vRNA-vRNA interactions challenges their role in influenza A virus genome packaging
Jakob C, Lovate GL, Desirò D, Gießler L, Smyth RP, Marquet R, Lamkiewicz K, Marz M, Schwemmle M, Bolte H (2023)
Nucleic Acids Research 51 (12): 6479-6494DOI: 10.1093/nar/gkad442
Nano-DMS-MaP allows isoform-specific RNA structure determination
Bohn P, Gribling-Burrer AS, Ambi UB, Smyth RP (2023)
Nature Methods 20 (6): 849-859DOI: 10.1038/s41592-023-01862-7
Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function
Pekarek L, Zimmer MM, Gribling-Burrer AS, Buck S, Smyth RP, Caliskan N (2023)
Nucleic Acids Research 51 (2): 728–743DOI: 10.1093/nar/gkac1184
2022
Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging
Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP (2022)
Nature Structural & Molecular Biology 29 (4): 306-319DOI: 10.1038/s41594-022-00746-2