Jun Prof Redmond Smyth


Redmond Smyth carried out his undergraduate degree in Natural Sciences at the University of Cambridge (UK), specializing in Virology and Immunology. He then moved to the Burnet Institute, Melbourne (Australia) for his PhD, where he investigated the mechanisms of HIV-1 genetic diversity in its natural target cells. His PhD research pointed to the importance of RNA structure in regulating viral infection processes, which is why he then moved to Strasbourg (France) for his post-doctoral research to train as an RNA biochemist. Here, he worked on understanding the mechanisms leading to the incorporation of the HIV-1 genomic RNA into viral particles. In 2015, he was recruited to the CNRS as a chargé de recherché (CR2), and in 2018, with support from the Helmholtz Association, he started his own research group at the Helmholtz Institute for RNA-based Infection Research (HIRI).


The evolution of RNA structural probing methods: From gels to next-generation sequencing

Mailler E, Paillart J, Marquet R, Smyth R, Vivet-Boudou V (2019)

Wiley Interdiscip Rev RNA, 10 (2)DOI: 10.1002/wrna.1518


Structural and Functional Motifs in Influenza Virus RNAs

Ferhadian D, Contrant M, Printz-Schweigert A, Smyth R, Paillart J, Marquet R (2018)

Front Microbiol, 9DOI: 10.3389/fmicb.2018.00559

In cell mutational interference mapping experiment (in cell MIME) identifies the 5' polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging

Smyth R, Smith M, Jousset A, Despons L, Laumond G, Decoville T, Cattenoz P, Moog C, Jossinet F, Mougel M, …, Kleist M, Marquet R (2018)

Nucleic Acids Res, 46 (9)DOI: 10.1093/nar/gky152

RNA Structure - A Neglected Puppet Master for the Evolution of Virus and Host Immunity

Smyth R, Negroni M, Lever A, Mak J, Kenyon J (2018)

Front Immunol, 9DOI: 10.3389/fimmu.2018.02097


HIV-1 Pr55Gag binds genomic and spliced RNAs with different affinity and stoichiometry

Bernacchi S, Abd El-Wahab E, Dubois N, Hijnen M, Smyth R, Mak J, Marquet R, Paillart J (2017)

RNA Biol, 14 (1): 90-103DOI: 10.1080/15476286.2016.1256533


HIV-1 Mutation and Recombination Rates Are Different in Macrophages and T-cells

Cromer D, Schlub T, Smyth R, Grimm A, Chopra A, Mallal S, Davenport M, Mak J (2016)

Viruses, 8 (4)DOI: 10.3390/v8040118

The Life-Cycle of the HIV-1 Gag-RNA Complex

Mailler E, Bernacchi S, Marquet R, Paillart J, Vivet-Boudou V, Smyth R (2016)

Viruses, 8 (9)DOI: 10.3390/v8090248

MIMEAnTo: profiling functional RNA in mutational interference mapping experiments

Smith M, Smyth R, Marquet R, Kleist M (2016)

Bioinformatics, 32 (21): 3369-3370DOI: 10.1093/bioinformatics/btw479

A step forward understanding HIV-1 diversity

Smyth R, Negroni M (2016)

Retrovirology, 13DOI: 10.1186/s12977-016-0259-8


Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection

Hawkes D, Jones K, Smyth R, Pereira C, Bittman R, Jaworowski A, Mak J (2015)

Virus Res, 210: 18-21DOI: 10.1016/j.virusres.2015.06.023

Mutational interference mapping experiment (MIME) for studying RNA structure and function

Smyth R, Despons L, Huili G, Bernacchi S, Hijnen M, Mak J, Jossinet F, Weixi L, Paillart J, Kleist M, Marquet R (2015)

Nat Methods, 12 (9): 866-72DOI: 10.1038/nmeth.3490

Evaluation of anti-HIV-1 mutagenic nucleoside analogues

Vivet-Boudou V, Isel C, El Safadi Y, Smyth R, Laumond G, Moog C, Paillart J, Marquet R (2015)

J Biol Chem, 290 (1): 371-83DOI: 10.1074/jbc.M114.616383


Fifteen to twenty percent of HIV substitution mutations are associated with recombination

Schlub T, Grimm A, Smyth R, Cromer D, Chopra A, Mallal S, Venturi V, Waugh C, Mak J, Davenport M (2014)

J Virol, 88 (7): 3837-49DOI: 10.1128/JVI.03136-13

Specific recognition of the HIV-1 genomic RNA by the Gag precursor

Abd El-Wahab E, Smyth R, Mailler E, Bernacchi S, Vivet-Boudou V, Hijnen M, Jossinet F, Mak J, Paillart J, Marquet R (2014)

Nat Commun, 5DOI: 10.1038/ncomms5304

Identifying recombination hot spots in the HIV-1 genome

Smyth R, Schlub T, Grimm A, Waugh C, Ellenberg P, Chopra A, Mallal S, Cromer D, Mak J, Davenport M (2014)

J Virol, 88 (5): 2891-902DOI: 10.1128/JVI.03014-13


Improved quantification of HIV-1-infected CD4+ T cells using an optimised method of intracellular HIV-1 gag p24 antigen detection

Yang H, Yorke E, Hancock G, Clutton G, Sande N, Angus B, Smyth R, Mak J, Dorrell L (2013)

J Immunol Methods, 391 (1-2): 174-8DOI: 10.1016/j.jim.2013.03.001

Intracellular Dynamics of HIV Infection

Petravic J, Ellenberg P, Chan M, Paukovics G, Smyth R, Mak J, Davenport M (2013)

J Virol, 88 (2): 1113-24DOI: 10.1128/JVI.02038-13

A functional sequence-specific interaction between influenza A virus genomic RNA segments

Gavazzi C, Yver M, Isel C, Smyth R, Rosa-Calatrava M, Lina B, Moulès V, Marquet R (2013)

Proc Natl Acad Sci U S A, 110 (41): 16604-9DOI: 10.1073/pnas.1314419110


The Origin of Genetic Diversity in HIV-1

Smyth R, Davenport M, Mak J (2012)

Virus Res, 169 (2): 415-29DOI: 10.1016/j.virusres.2012.06.015


8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription

Vivet-Boudou V, Isel C, Sleiman M, Smyth R, Ben Gaied N, Barhoum P, Laumond G, Bec G, Götte M, Mak J, …, Burger A, Marquet R (2011)

Plos One, 6 (11)DOI: 10.1371/journal.pone.0027456

Labeling of multiple HIV-1 proteins with the biarsenical-tetracysteine system

Pereira C, Ellenberg P, Jones K, Fernandez T, Smyth R, Hawkes D, Hijnen M, Vivet-Boudou V, Marquet R, Johnson I, Mak J (2011)

Plos One, 6 (2)DOI: 10.1371/journal.pone.0017016

Early events of HIV-1 infection: can signaling be the next therapeutic target?

Jones K, Smyth R, Pereira C, Cameron P, Lewin S, Jaworowski A, Mak J (2011)

J Neuroimmune Pharmacol, 6 (2): 269-83DOI: 10.1007/s11481-011-9268-5


Reducing chimera formation during PCR amplification to ensure accurate genotyping

Smyth R, Schlub T, Grimm A, Venturi V, Chopra A, Mallal S, Davenport M, Mak J (2010)

Gene, 469 (1-2): 45-51DOI: 10.1016/j.gene.2010.08.009

Accurately measuring recombination between closely related HIV-1 genomes

Schlub T, Smyth R, Grimm A, Mak J, Davenport M (2010)

PLos Comput Biol, 6 (4)DOI: 10.1371/journal.pcbi.1000766


The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA

Keating C, Hill M, Hawkes D, Smyth R, Isel C, Le S, Palmenberg A, Marshall J, Marquet R, Nabel G, Mak J (2009)

Nucleic Acids Res, 37 (3): 945-56DOI: 10.1093/nar/gkn1015

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