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Prof Jörg Vogel

About

Prof. Jörg Vogel is the founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) as well as the director of the Institute of Molecular Infection Biology (IMIB) at the University of Würzburg, Germany. As world-leading scientist in the field of RNA biology, Jörg Vogel is considered a pioneer in the application and development of high-throughput sequencing methods for the analysis of individual infected cells as well as interactions between pathogenic bacteria and their hosts. 

Prof. Jörg Vogel studied biochemistry at Humboldt University, Berlin, Germany, and at Imperial College, London, UK. In 1999, he received his PhD from Humboldt University with a thesis on Group II intron splicing. He spent his postdoctoral years at Uppsala University, Sweden (2000-2001) and as an EMBO fellow at the Hebrew University, Jerusalem, Israel (2002-2003) before he started an Independent Junior Research Group at the Max Planck Institute for Infection Biology in Berlin, Germany (2004-2010). He became Full Professor and Director of the Institute for Molecular Infection Biology at the University of Würzburg in 2009. As of 2017, he is the Director of the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg.

Jörg Vogel is an elected member of EMBO, the German National Academy of Sciences, as well as the European and American Academies of Microbiology. In 2017, he received a Leibniz Prize, Germany’s most prestigious research award, for his ground-breaking contributions to the understanding of regulatory RNA molecules in infection biology.

Prof. Vogel’s group seek to understand the full (noncoding) RNA world of bacterial pathogens and use RNA-centric approaches to targeting pathogens and manipulating microbiota. A major innovative goal is the comprehensive simultaneous RNA-based profiling of the pathogen and the infected host in real time and at single-cell resolution; where applicable, this should also include co-colonizing microbiota. Researchers at the Vogel lab focus on the mode of action of those noncoding RNA molecules that are crucial for the virulence of the pathogen, differentially expressed upon exposure to the host, or impact gene expression in interacting members of the microbiota. The knowledge obtained will be exploited for therapeutic intervention with clinically relevant bacterial pathogens.


hopi - Alexander Westermann

Host-Pathogen Transcriptomics by Dual RNA-Seq

Westermann A, Vogel J, (2018)

Contribution, 1737, 59-75, 10.1007/978-1-4939-7634-8_4, 29484587

Einzelzell-RNA-Sequenzierung beleuchtet den Infektionsprozess

Saliba A, Westermann A, Vogel J, (2017)

Biospektrum, 23, 5, 525-528, 10.1007/s12268-017-0836-y,

Resolving host-pathogen interactions by dual RNA-seq

Westermann A, Barquist L, Vogel J, (2017)

PLoS pathogens, 13, 2, 10.1371/journal.ppat.1006033, 28207848

Molecular phenotyping of infection-associated small non-coding RNAs

Barquist L, Westermann A, Vogel J, (2016)

Philos. Trans. R. Soc. Lond., B, Biol. Sci., 371, 1707, 10.1098/rstb.2016.0081, 27672158

Single-cell RNA-seq: advances and future challenges

Saliba A, Westermann A, Gorski S, Vogel J, (2014)

Nucleic acids research, 42, 14, 8845-60, 10.1093/nar/gku555, 25053837

iiib - Lars Barquist

Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3' Ends

Holmqvist E, Li L, Bischler T, Barquist L, Vogel J, (2018)

Molecular cell, 70, 5, 971-982, 10.1016/j.molcel.2018.04.017, 29804828

RNA target profiles direct the discovery of virulence functions for the cold-shock proteins CspC and CspE

Michaux C, Holmqvist E, Vasicek E, Sharan M, Barquist L, Westermann A, Gunn J, Vogel J, (2017)

Proceedings of the National Academy of Sciences of the United States of America, 114, 26, 6824-6829, 10.1073/pnas.1620772114, 28611217

Global RNA recognition patterns of post-transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo

Holmqvist E, Wright P, Li L, Bischler T, Barquist L, Reinhardt R, Backofen R, Vogel J, (2016)

The EMBO journal, 35, 9, 991-1011, 10.15252/embj.201593360, 27044921

Accelerating Discovery and Functional Analysis of Small RNAs with New Technologies

Barquist L, Vogel J, (2015)

Annual review of genetics, 49, 367-94, 10.1146/annurev-genet-112414-054804, 26473381

lrib - Mathias Munschauer

Nuclear lncRNA stabilization in the host response to bacterial infection

Munschauer M, Vogel J, (2018)

The EMBO journal, 37, 13, 10.15252/embj.201899875, 29934294

rabi - Jörg Vogel

The CRISPR/Cas system in Neisseria meningitidis affects bacterial adhesion to human nasopharyngeal epithelial cells

Heidrich N, Hagmann A, Bauriedl S, Vogel J, Schoen C, (2019)

RNA biology, 16, 4, 390-396, 10.1080/15476286.2018.1486660, 30059276

The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium

Westermann A, Venturini E, Sellin M, Förstner K, Hardt W, Vogel J, (2019)

MBio, 10, 1, 10.1128/mBio.02504-18, 30602583

Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA

Miyakoshi M, Matera G, Maki K, Sone Y, Vogel J, (2019)

Nucleic acids research, 47, 4, 2075-2088, 10.1093/nar/gky1243, 30541135

CRP-cAMP mediates silencing of Salmonella virulence at the post-transcriptional level

El Mouali Y, Gaviria-Cantin T, Sánchez-Romero M, Gibert M, Westermann A, Vogel J, Balsalobre C, (2018)

PLoS genetics, 14, 6, 10.1371/journal.pgen.1007401, 29879120

ANNOgesic: a Swiss army knife for the RNA-seq based annotation of bacterial/archaeal genomes

Yu S, Vogel J, Förstner K, (2018)

Gigascience, 7, 9, 10.1093/gigascience/giy096, 30169674

siga - Emmanuel Saliba

New RNA-seq approaches for the study of bacterial pathogens

Saliba A, C Santos S, Vogel J, (2017)

Current opinion in microbiology, 35, 78-87, 10.1016/j.mib.2017.01.001, 28214646

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