Prof Jörg Vogel
About
Prof. Jörg Vogel is the founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) as well as the director of the Institute of Molecular Infection Biology (IMIB) at the University of Würzburg, Germany. As world-leading scientist in the field of RNA biology, Jörg Vogel is considered a pioneer in the application and development of high-throughput sequencing methods for the analysis of individual infected cells as well as interactions between pathogenic bacteria and their hosts.
Prof. Jörg Vogel studied biochemistry at Humboldt University, Berlin, Germany, and at Imperial College, London, UK. In 1999, he received his PhD from Humboldt University with a thesis on Group II intron splicing. He spent his postdoctoral years at Uppsala University, Sweden (2000-2001) and as an EMBO fellow at the Hebrew University, Jerusalem, Israel (2002-2003) before he started an Independent Junior Research Group at the Max Planck Institute for Infection Biology in Berlin, Germany (2004-2010). He became Full Professor and Director of the Institute for Molecular Infection Biology at the University of Würzburg in 2009. As of 2017, he is the Director of the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg.
Jörg Vogel is an elected member of EMBO, the German National Academy of Sciences, as well as the European and American Academies of Microbiology. In 2017, he received a Leibniz Prize, Germany’s most prestigious research award, for his ground-breaking contributions to the understanding of regulatory RNA molecules in infection biology.
Prof. Vogel’s group seek to understand the full (noncoding) RNA world of bacterial pathogens and use RNA-centric approaches to targeting pathogens and manipulating microbiota. A major innovative goal is the comprehensive simultaneous RNA-based profiling of the pathogen and the infected host in real time and at single-cell resolution; where applicable, this should also include co-colonizing microbiota. Researchers at the Vogel lab focus on the mode of action of those noncoding RNA molecules that are crucial for the virulence of the pathogen, differentially expressed upon exposure to the host, or impact gene expression in interacting members of the microbiota. The knowledge obtained will be exploited for therapeutic intervention with clinically relevant bacterial pathogens.
2022
An overview of gene regulation in bacteria by small RNAs derived from mRNA 3' ends
Ponath F, Hör J, Vogel J (2022)
FEMS Microbiology ReviewsDOI: 10.1093/femsre/fuac017
Global RNA interactome of Salmonella discovers a 5' UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
Matera G, Altuvia Y, Gerovac M, El Mouali Y, Margalit H, Vogel J (2022)
Molecular Cell 82 (3): 629-644DOI: 10.1016/j.molcel.2021.12.030
The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner
Gomez-Raya-Vilanova MV, Leskinen K, Bhattacharjee A, Virta P, Rosenqvist P, Smith JLR, Bayfield OW, Homberger C, Kerrinnes T, Vogel J, Pajunen MI, Skurnik M (2022)
Nucleic Acids Research 50 (7): 3985-3997DOI: 10.1093/nar/gkac203
Innovative developments and emerging technologies in RNA therapeutics
Halloy F, Biscans A, Bujold KE, Debacker A, Hill AC, Lacroix A, Luige O, Strömberg R, Sundstrom L, Vogel J, Ghidini A (2022)
RNA Biology 19 (1): 313-332DOI: 10.1080/15476286.2022.2027150
2021
Impact of pseudouridylation, substrate fold, and degradosome organization on the endonuclease activity of RNase E
Islam MS, Bandyra KJ, Chao Y, Vogel J, Luisi BF (2021)
RNA 27 (11): 1339-1352DOI: 10.1261/rna.078840.121
SPI2 T3SS effectors facilitate enterocyte apical to basolateral transmigration of Salmonella-containing vacuoles in vivo
Fulde M, van Vorst K, Zhang K, Westermann AJ, Busche T, Huei YC, Welitschanski K, Froh I, Pägelow D, Plendl J, …, Repnik U, Hornef MW (2021)
Gut Microbes 13 (1): 1973836DOI: 10.1080/19490976.2021.1973836
Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease
El Mouali Y, Ponath F, Scharrer V, Wenner N, Hinton JCD, Vogel J (2021)
RNA 27 (12): 1512-1527DOI: 10.1261/rna.078954.121
An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium
Fuchs M, Lamm-Schmidt V, Sulzer J, Ponath F, Jenniches L, Kirk JA, Fagan RP, Barquist L, Vogel J, Faber F (2021)
Proceedings of the National Academy of Sciences of the United States of America 118 (25)DOI: 10.1073/pnas.2103579118
RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum
Ponath F, Tawk C, Zhu Y, Barquist L, Faber F, Vogel J (2021)
Nature Microbiology 6 (8): 1007-1020DOI: 10.1038/s41564-021-00927-7
The World of Stable Ribonucleoproteins and Its Mapping With Grad-Seq and Related Approaches
Gerovac M, Vogel J, Smirnov A (2021)
Frontiers in Molecular Biosciences 8: 661448DOI: 10.3389/fmolb.2021.661448
In vivo targets of Salmonella FinO include a FinP-like small RNA controlling copy number of a cohabitating plasmid
El Mouali Y, Gerovac M, Mineikaite R, Vogel J (2021)
Nucleic Acids Research 49 (9): 5319-5335DOI: 10.1093/nar/gkab281
Analysis of the RNA and Protein Complexome by Grad-seq
Hör J, Vogel J (2021)
Methods in Molecular Biology 2300: 183-201DOI: 10.1007/978-1-0716-1386-3_16
Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics
Popella L, Jung J, Popova K, Ðurica-Mitic S, Barquist L, Vogel J (2021)
Nucleic Acids Research 49 (8): 4705-4724DOI: 10.1093/nar/gkab242
A Grad-seq View of RNA and Protein Complexes in Pseudomonas aeruginosa under Standard and Bacteriophage Predation Conditions
Gerovac M, Wicke L, Chihara K, Schneider C, Lavigne R, Vogel J (2021)
mBio 12 (1): 03454-20DOI: 10.1128/mBio.03454-20
MAPS integrates regulation of actin-targeting effector SteC into the virulence control network of Salmonella small RNA PinT
Correia Santos S, Bischler T, Westermann AJ, Vogel J (2021)
Cell Reports 34 (5): 108722DOI: 10.1016/j.celrep.2021.108722
Cross-species RNA-seq for deciphering host–microbe interactions
Westermann AJ, Vogel J (2021)
Nature Reviews Genetics 22 (6): 361DOI: 10.1038/s41576-021-00326-y
A genome-wide transcriptomic analysis of embryos fathered by obese males in a murine model of diet-induced obesity
Bernhardt L, Dittrich M, El-Merahbi R, Saliba A, Müller T, Sumara G, Vogel J, Nichols-Burns S, Mitchell M, Haaf T, El Hajj N (2021)
Scientific Reports 11: 1979DOI: 10.1038/s41598-021-81226-3
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia
Chumduri C, Gurumurthy RK, Berger H, Dietrich O, Kumar N, Koster S, Brinkmann V, Hoffmann K, Drabkina M, Arampatzi P, …, Saliba A, Meyer TF (2021)
Nature Cell Biology 23 (2): 184DOI: 10.1038/s41556-020-00619-0
Introducing differential RNA-seq mapping to track the early infection phase for Pseudomonas phage ɸKZ
Wicke L, Ponath F, Coppens L, Gerovac M, Lavigne R, Vogel J (2021)
RNA Biology 18 (8): 1099-1110DOI: 10.1080/15476286.2020.1827785