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Prof Jörg Vogel

About

Prof. Jörg Vogel is the founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) as well as the director of the Institute of Molecular Infection Biology (IMIB) at the University of Würzburg, Germany. As world-leading scientist in the field of RNA biology, Jörg Vogel is considered a pioneer in the application and development of high-throughput sequencing methods for the analysis of individual infected cells as well as interactions between pathogenic bacteria and their hosts. 

Prof. Jörg Vogel studied biochemistry at Humboldt University, Berlin, Germany, and at Imperial College, London, UK. In 1999, he received his PhD from Humboldt University with a thesis on Group II intron splicing. He spent his postdoctoral years at Uppsala University, Sweden (2000-2001) and as an EMBO fellow at the Hebrew University, Jerusalem, Israel (2002-2003) before he started an Independent Junior Research Group at the Max Planck Institute for Infection Biology in Berlin, Germany (2004-2010). He became Full Professor and Director of the Institute for Molecular Infection Biology at the University of Würzburg in 2009. As of 2017, he is the Director of the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg.

Jörg Vogel is an elected member of EMBO, the German National Academy of Sciences, as well as the European and American Academies of Microbiology. In 2017, he received a Leibniz Prize, Germany’s most prestigious research award, for his ground-breaking contributions to the understanding of regulatory RNA molecules in infection biology.

Prof. Vogel’s group seek to understand the full (noncoding) RNA world of bacterial pathogens and use RNA-centric approaches to targeting pathogens and manipulating microbiota. A major innovative goal is the comprehensive simultaneous RNA-based profiling of the pathogen and the infected host in real time and at single-cell resolution; where applicable, this should also include co-colonizing microbiota. Researchers at the Vogel lab focus on the mode of action of those noncoding RNA molecules that are crucial for the virulence of the pathogen, differentially expressed upon exposure to the host, or impact gene expression in interacting members of the microbiota. The knowledge obtained will be exploited for therapeutic intervention with clinically relevant bacterial pathogens.


2023

RNA recording in single bacterial cells using reprogrammed tracrRNAs

Jiao C, Reckstadt C, König F, Homberger C, Yu J, Vogel J, Westermann AJ, Sharma CM, Beisel CL (2023)

Nature Biotechnology (Online ahead of print)DOI: 10.1038/s41587-022-01604-8

A MATQ-seq-Based Protocol for Single-Cell RNA-seq in Bacteria

Homberger C, Saliba A, Vogel J (2023)

Methods in Molecular Biology 2584: 105-121DOI: 10.1007/978-1-0716-2756-3_4

2022

Hypothalamic integrity is necessary for sustained weight loss after bariatric surgery: A prospective, cross-sectional study

Dischinger U, Kötzner L, Kovatcheva-Datchary P, Kleinschmidt H, Haas C, Perez J, Presek C, Koschker AC, Miras AD, Hankir MK, …, Herrmann MJ, Seyfried F (2022)

Metabolism: Clinical and Experimental 138: 155341DOI: 10.1016/j.metabol.2022.155341

Global profiling of the RNA and protein complexes of Escherichia coli by size exclusion chromatography followed by RNA sequencing and mass spectrometry (SEC-seq)

Chihara K, Gerovac M, Hör J, Vogel J (2022)

RNA (Online ahead of print)DOI: 10.1261/rna.079439.122

An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs

Schneider C, Erhard F, Binotti B, Buchberger A, Vogel J, Fischer U (2022)

Cell Reports 41 (2): 111467DOI: 10.1016/j.celrep.2022.111467

INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors

Hör J, Jung J, Ðurica-Mitic S, Barquist L, Vogel J (2022)

Nucleic Acids Research (Online ahead of print)DOI: 10.1093/nar/gkac838

Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum

Ponath F, Zhu Y, Cosi V, Vogel J (2022)

PNAS 119 (40): 2201460DOI: 10.1073/pnas.2201460119

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, Bremser A, Polyzou A, Obier N, Cabezas-Wallscheid N, …, Westermann AJ, Rambold AS (2022)

Nature Metabolism 4 (7): 856-866DOI: 10.1038/s42255-022-00605-w

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli

Popella L, Jung J, Do PT, Hayward RJ, Barquist L, Vogel J (2022)

Nucleic Acids Research 50 (11): 6435DOI: 10.1093/nar/gkac362

Cellular RNA Targets of Cold Shock Proteins CspC and CspE and Their Importance for Serum Resistance in Septicemic Escherichia coli

Yair Y, Michaux C, Biran D, Bernhard J, Vogel J, Barquist L, Ron EZ (2022)

mSystems 7 (4): 0008622DOI: 10.1128/msystems.00086-22

An overview of gene regulation in bacteria by small RNAs derived from mRNA 3' ends

Ponath F, Hör J, Vogel J (2022)

FEMS Microbiology Reviews 46 (5): 017DOI: 10.1093/femsre/fuac017

Global RNA interactome of Salmonella discovers a 5' UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity

Matera G, Altuvia Y, Gerovac M, El Mouali Y, Margalit H, Vogel J (2022)

Molecular Cell 82 (3): 629-644DOI: 10.1016/j.molcel.2021.12.030

The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner

Gomez-Raya-Vilanova MV, Leskinen K, Bhattacharjee A, Virta P, Rosenqvist P, Smith JLR, Bayfield OW, Homberger C, Kerrinnes T, Vogel J, Pajunen MI, Skurnik M (2022)

Nucleic Acids Research 50 (7): 3985-3997DOI: 10.1093/nar/gkac203

Innovative developments and emerging technologies in RNA therapeutics

Halloy F, Biscans A, Bujold KE, Debacker A, Hill AC, Lacroix A, Luige O, Strömberg R, Sundstrom L, Vogel J, Ghidini A (2022)

RNA Biology 19 (1): 313-332DOI: 10.1080/15476286.2022.2027150