
Prof Jörg Vogel
About
Prof. Jörg Vogel is the founding director of the Helmholtz Institute for RNA-based Infection Research (HIRI) as well as the director of the Institute of Molecular Infection Biology (IMIB) at the University of Würzburg, Germany. As world-leading scientist in the field of RNA biology, Jörg Vogel is considered a pioneer in the application and development of high-throughput sequencing methods for the analysis of individual infected cells as well as interactions between pathogenic bacteria and their hosts.
Prof. Jörg Vogel studied biochemistry at Humboldt University, Berlin, Germany, and at Imperial College, London, UK. In 1999, he received his PhD from Humboldt University with a thesis on Group II intron splicing. He spent his postdoctoral years at Uppsala University, Sweden (2000-2001) and as an EMBO fellow at the Hebrew University, Jerusalem, Israel (2002-2003) before he started an Independent Junior Research Group at the Max Planck Institute for Infection Biology in Berlin, Germany (2004-2010). He became Full Professor and Director of the Institute for Molecular Infection Biology at the University of Würzburg in 2009. As of 2017, he is the Director of the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg.
Jörg Vogel is an elected member of EMBO, the German National Academy of Sciences, as well as the European and American Academies of Microbiology. In 2017, he received a Leibniz Prize, Germany’s most prestigious research award, for his ground-breaking contributions to the understanding of regulatory RNA molecules in infection biology.
Prof. Vogel’s group seek to understand the full (noncoding) RNA world of bacterial pathogens and use RNA-centric approaches to targeting pathogens and manipulating microbiota. A major innovative goal is the comprehensive simultaneous RNA-based profiling of the pathogen and the infected host in real time and at single-cell resolution; where applicable, this should also include co-colonizing microbiota. Researchers at the Vogel lab focus on the mode of action of those noncoding RNA molecules that are crucial for the virulence of the pathogen, differentially expressed upon exposure to the host, or impact gene expression in interacting members of the microbiota. The knowledge obtained will be exploited for therapeutic intervention with clinically relevant bacterial pathogens.
2023
Gut Microbiota Contribution to Weight-Independent Glycemic Improvements after Gastric Bypass Surgery
Hankir MK, Kovatcheva-Datchary P, Springer R, Hoffmann A, Vogel J, Seyfried F, Arora T (2023)
Microbiology Spectrum (Online ahead of print)DOI: 10.1128/spectrum.05109-22
Improved Bacterial Single-Cell RNA-Seq through Automated MATQ-Seq and Cas9-Based Removal of rRNA Reads
Homberger C, Hayward RJ, Barquist L, Vogel J (2023)
mBio (Online ahead of print)DOI: 10.1128/mbio.03557-22
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection
Däullary T, Imdahl F, Dietrich O, Hepp L, Krammer T, Fey C, Neuhaus W, Metzger M, Vogel J, Westermann AJ, Saliba AE, Zdzieblo D (2023)
Gut Microbes 15 (1): 2186109DOI: 10.1080/19490976.2023.2186109
Design and off-target prediction for antisense oligomers targeting bacterial mRNAs with the MASON webserver
Jung JJ, Popella L, Do PT, Pfau P, Vogel J, Barquist L (2023)
RNA (Online ahead of print)DOI: 10.1261/rna.079263.122
RNA recording in single bacterial cells using reprogrammed tracrRNAs
Jiao C, Reckstadt C, König F, Homberger C, Yu J, Vogel J, Westermann AJ, Sharma CM, Beisel CL (2023)
Nature Biotechnology (Online ahead of print)DOI: 10.1038/s41587-022-01604-8
A MATQ-seq-Based Protocol for Single-Cell RNA-seq in Bacteria
Homberger C, Saliba AE, Vogel J (2023)
Methods in Molecular Biology 2584: 105-121DOI: 10.1007/978-1-0716-2756-3_4
2022
Hypothalamic integrity is necessary for sustained weight loss after bariatric surgery: A prospective, cross-sectional study
Dischinger U, Kötzner L, Kovatcheva-Datchary P, Kleinschmidt H, Haas C, Perez J, Presek C, Koschker AC, Miras AD, Hankir MK, …, Herrmann MJ, Seyfried F (2022)
Metabolism: Clinical and Experimental 138: 155341DOI: 10.1016/j.metabol.2022.155341
Global profiling of the RNA and protein complexes of Escherichia coli by size exclusion chromatography followed by RNA sequencing and mass spectrometry (SEC-seq)
Chihara K, Gerovac M, Hör J, Vogel J (2022)
RNA (Online ahead of print)DOI: 10.1261/rna.079439.122
An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
Schneider C, Erhard F, Binotti B, Buchberger A, Vogel J, Fischer U (2022)
Cell Reports 41 (2): 111467DOI: 10.1016/j.celrep.2022.111467
INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors
Hör J, Jung J, Ðurica-Mitic S, Barquist L, Vogel J (2022)
Nucleic Acids Research 50 (22): 128DOI: 10.1093/nar/gkac838
Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum
Ponath F, Zhu Y, Cosi V, Vogel J (2022)
PNAS 119 (40): 2201460DOI: 10.1073/pnas.2201460119
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages
Schuster EM, Epple MW, Glaser KM, Mihlan M, Lucht K, Zimmermann JA, Bremser A, Polyzou A, Obier N, Cabezas-Wallscheid N, …, Westermann AJ, Rambold AS (2022)
Nature Metabolism 4 (7): 856-866DOI: 10.1038/s42255-022-00605-w
Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli
Popella L, Jung J, Do PT, Hayward RJ, Barquist L, Vogel J (2022)
Nucleic Acids Research 50 (11): 6435DOI: 10.1093/nar/gkac362
Cellular RNA Targets of Cold Shock Proteins CspC and CspE and Their Importance for Serum Resistance in Septicemic Escherichia coli
Yair Y, Michaux C, Biran D, Bernhard J, Vogel J, Barquist L, Ron EZ (2022)
mSystems 7 (4): 0008622DOI: 10.1128/msystems.00086-22
An overview of gene regulation in bacteria by small RNAs derived from mRNA 3' ends
Ponath F, Hör J, Vogel J (2022)
FEMS Microbiology Reviews 46 (5): 017DOI: 10.1093/femsre/fuac017
Global RNA interactome of Salmonella discovers a 5' UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
Matera G, Altuvia Y, Gerovac M, El Mouali Y, Margalit H, Vogel J (2022)
Molecular Cell 82 (3): 629-644DOI: 10.1016/j.molcel.2021.12.030
The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner
Gomez-Raya-Vilanova MV, Leskinen K, Bhattacharjee A, Virta P, Rosenqvist P, Smith JLR, Bayfield OW, Homberger C, Kerrinnes T, Vogel J, Pajunen MI, Skurnik M (2022)
Nucleic Acids Research 50 (7): 3985-3997DOI: 10.1093/nar/gkac203
Innovative developments and emerging technologies in RNA therapeutics
Halloy F, Biscans A, Bujold KE, Debacker A, Hill AC, Lacroix A, Luige O, Strömberg R, Sundstrom L, Vogel J, Ghidini A (2022)
RNA Biology 19 (1): 313-332DOI: 10.1080/15476286.2022.2027150