Scientists at the HIRI develop RNA-centric approaches to unravel the complex mechanisms associated with infectious diseases.
Rising antimicrobial resistance, chronic infections, and (re-) emerging pathogens are among the major challenges facing humanity. RNA is increasingly understood to contribute to key regulatory and sensory processes in the cell, but the role of RNA in infection biology remains understudied.
Research at HIRI aims to close this gap by combining interdisciplinary expertise with cutting-edge research infrastructure to exploit the vast potential of RNA as a diagnostic molecule, target, and drug to combat infectious disease.
Developing innovative delivery techniques for RNA-based interventions
Understanding RNA-based mechanisms in virulence and host defence
Identifying novel regulatory RNAs with key roles in pathogenesis
Resolving the complexity and heterogeneity of infection processes at the single-cell level
Exploiting RNA knowledge for new diagnostics, preventives, and anti-infectives