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Developing antisense oligomer biotics "asobiotics" as precision antibacterials: designs, strategies, and considerations for future success
Publication
Moustafa DA,
Ghosh C,
Jung J,
Nanayakkara A,
Sapkota M,
Nagamatsu K,
Geller B,
Vogel J,
Goldberg JB,
Greenberg DE
(2026)
FEMS Microbiology Reviews, 50, fuaf059, 10.1093/femsre/fuaf059, 41384796
FEMS Microbiology Reviews, 50, fuaf059, 10.1093/femsre/fuaf059, 41384796
A ribosome-interacting jumbophage protein associates with the phage nucleus to facilitate efficient propagation
Publication
Wannasrichan W,
Krobthong S,
Morgan CJ,
Armbruster EG,
Gerovac M,
Yingchutrakul Y,
Wongtrakoongate P,
Vogel J,
Aonbangkhen C,
Nonejuie P,
Pogliano J,
Chaikeeratisak V
(2025)
PLOS Pathogens, 21, 2, e1012936, 10.1371/journal.ppat.1012936, 39992933
PLOS Pathogens, 21, 2, e1012936, 10.1371/journal.ppat.1012936, 39992933
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Publication
Garcia-Campos MA,
Georgeson J,
Nir R,
Reichelt R,
Fluke KA,
Matzov D,
Iyer V,
Burkhart BW,
Lui L,
Kustanovich A,
Grünberger F,
Thalalla-Gamage S,
Howpay-Manage SA,
Gerovac M,
Alexandre N,
Nobe Y,
Nowak JS,
Perera M,
Apostle A,
Fang S,
Glatt S,
Jona G,
Ferreira-Cerca S,
Vogel J,
Taoka M,
Meier JL,
Westhof E,
Santangelo TJ,
Grohmann D,
Shalev-Benami M,
Schwartz S,
Garcia-Campos MA,
Georgeson J,
Nir R,
Reichelt R,
Fluke KA,
Matzov D,
Iyer V,
Burkhart BW,
Lui L,
Kustanovich A,
Grünberger F,
Thalalla-Gamage S,
Howpay-Manage SA,
Gerovac M,
Alexandre N,
Nobe Y,
Nowak JS,
Perera M,
Apostle A,
Fang S,
Glatt S,
Jona G,
Ferreira-Cerca S,
Vogel J,
Taoka M,
Meier JL,
Westhof E,
Santangelo TJ,
Grohmann D,
Shalev-Benami M,
Schwartz S
(2025)
Cell, 188, 24, 6825-6844.e28, 10.1016/j.cell.2025.09.014, 41130207
Cell, 188, 24, 6825-6844.e28, 10.1016/j.cell.2025.09.014, 41130207
Fusobacterium nucleatum interacts with cancer-associated fibroblasts to promote colorectal cancer
Publication
Karta J,
Meyers M,
Rodriguez F,
Koncina E,
Gilson C,
Klein E,
Gabola M,
Benzarti M,
Pérez Escriva P,
Molina Tijeras JA,
Correia Tavares Bernardino C,
Ponath F,
Carpentier A,
Pujabet MA,
Schmoetten M,
Tsenkova M,
Saoud P,
Gaigneaux A,
Ternes D,
Alonso L,
Zügel N,
Willemssen E,
Koppes P,
Léonard D,
Casanova LP,
Haan S,
Mittelbronn M,
Meiser J,
Pozdeev VI,
Vogel J,
Nuciforo PG,
Wilmes P,
Letellier E,
Karta J,
Meyers M,
Rodriguez F,
Koncina E,
Gilson C,
Klein E,
Gabola M,
Benzarti M,
Pérez Escriva P,
Molina Tijeras JA,
Correia Tavares Bernardino C,
Ponath F,
Carpentier A,
Pujabet MA,
Schmoetten M,
Tsenkova M,
Saoud P,
Gaigneaux A,
Ternes D,
Alonso L,
Zügel N,
Willemssen E,
Koppes P,
Léonard D,
Casanova LP,
Haan S,
Mittelbronn M,
Meiser J,
Pozdeev VI,
Vogel J,
Nuciforo PG,
Wilmes P,
Letellier E
(2025)
The EMBO Journal, 44, 19, 10.1038/s44318-025-00542-w, 40846900
The EMBO Journal, 44, 19, 10.1038/s44318-025-00542-w, 40846900
RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers
Publication
Sarkar P,
Popella L,
Pérez-Jiménez S,
Vogel J
(2025)
mBio, 16, 4, e0398324, 10.1128/mbio.03983-24, 40035593
mBio, 16, 4, e0398324, 10.1128/mbio.03983-24, 40035593
Programmable antisense oligomers for phage functional genomics
Publication
Gerovac M,
Buhlmann L,
Zhu Y,
Ðurica-Mitic S,
Rech V,
Carien S,
Gräfenhan T,
Popella L,
Vogel J,
Gerovac M,
Buhlmann L,
Zhu Y,
Ðurica-Mitic S,
Rech V,
Carien S,
Gräfenhan T,
Popella L,
Vogel J
(2025)
Nature, 646, 8087, 1195-1203, 10.1038/s41586-025-09499-6, 40931073
Nature, 646, 8087, 1195-1203, 10.1038/s41586-025-09499-6, 40931073
A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics
Publication
Ghosh C,
Popella L,
Dhamodharan V,
Jung J,
Dietzsch J,
Barquist L,
Höbartner C,
Vogel J
(2024)
RNA, 30, 6, 624-643, 10.1261/rna.079969.124, 38413166
RNA, 30, 6, 624-643, 10.1261/rna.079969.124, 38413166
The RNA landscape of the human commensal Segatella copri reveals a small RNA essential for gut colonization
Publication
El Mouali Y,
Tawk C,
Huang KD,
Amend L,
Lesker TR,
Ponath F,
Vogel J,
Strowig T
(2024)
Cell Host & Microbe, 32, 11, 1910-1926.e6, 10.1016/j.chom.2024.09.008, 39368472
Cell Host & Microbe, 32, 11, 1910-1926.e6, 10.1016/j.chom.2024.09.008, 39368472
Cooperation of regulatory RNA and the RNA degradosome in transcript surveillance
Publication
Bandyra KJ,
Fröhlich KS,
Vogel J,
Rodnina M,
Goyal A,
Luisi BF
(2024)
Nucleic Acids Research, 52, 15, 9161-9173, 10.1093/nar/gkae455, 38842944
Nucleic Acids Research, 52, 15, 9161-9173, 10.1093/nar/gkae455, 38842944
Global Hfq-mediated RNA interactome of nitrogen starved Escherichia coli uncovers a conserved post-transcriptional regulatory axis required for optimal growth recovery
Publication
McQuail J,
Matera G,
Gräfenhan T,
Bischler T,
Haberkant P,
Stein F,
Vogel J,
Wigneshweraraj S
(2024)
Nucleic Acids Research, 52, 5, 2323-2339, 10.1093/nar/gkad1211, 38142457
Nucleic Acids Research, 52, 5, 2323-2339, 10.1093/nar/gkad1211, 38142457