Jun Prof Neva Caliskan
About
Neva Caliskan studied molecular biology and genetics at the Middle East Technical University in Ankara (Turkey) and worked as a visiting scholar in 2005 at EMBL in Heidelberg. She received her Master's degree at the International Max Planck Research School for Molecular Biology (Göttingen) in 2009. After completing her PhD in 2013, she first worked as a postdoctoral fellow at the Department of Physical Biochemistry at the Max Planck Institute for Biophysical Chemistry and then as a project leader at the same institute from 2015-2017. Since January 2018 she has been heading the junior research group "Recoding Mechanisms in Infections" at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg. As of May 2018 she holds a junior professorship at the Faculty of Medicine of the University of Würzburg.
2023
SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, …, Erhard F, Munschauer M (2023)
Cell 186 (22): 4834-4850.e23DOI: 10.1016/j.cell.2023.09.002
Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses
Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M, Caliskan N, Brown RJP, Steinmann E, Pietschmann T (2023)
Microbiology Spectrum 11 (4): e0128423DOI: 10.1128/spectrum.01284-23
Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function
Pekarek L, Zimmer MM, Gribling-Burrer AS, Buck S, Smyth RP, Caliskan N (2023)
Nucleic Acids Research 51 (2): 728–743DOI: 10.1093/nar/gkac1184
2022
Editorial: mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation
Kiss DL, Vasudevan D, Ho CK, Caliskan N (2022)
Frontiers in Molecular Biosciences 9: 947516DOI: 10.3389/fmolb.2022.947516
POTATO: Automated pipeline for batch analysis of optical tweezers data
Buck S, Pekarek L, Caliskan N (2022)
Biophysical Journal 121 (15): 2830-2839DOI: 10.1016/j.bpj.2022.06.030
Insights from structural studies of the cardiovirus 2A protein
Caliskan N, Hill CH (2022)
Bioscience Reports 42 (1): BSR20210406DOI: 10.1042/BSR20210406
Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation
Pekarek L, Buck S, Caliskan N (2022)
Journal of Visualized Experiments (180)DOI: 10.3791/62589
Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting
Riegger RJ, Caliskan N (2022)
Frontiers in Molecular Biosciences 9: 842261DOI: 10.3389/fmolb.2022.842261
Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging
Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP (2022)
Nature Structural & Molecular Biology 29 (4): 306-319DOI: 10.1038/s41594-022-00746-2
Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA
Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL (2022)
Nature Microbiology 7 (4): 530-541DOI: 10.1038/s41564-022-01074-3
2021
Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
Hill CH, Pekarek L, Napthine S, Kibe A, Firth AE, Graham SC, Caliskan N, Brierley I (2021)
Nature Communications 12 (1): 7166DOI: 10.1038/s41467-021-27400-7
Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus
Hill CH, Cook GM, Napthine S, Kibe A, Brown K, Caliskan N, Firth AE, Graham SC, Brierley I (2021)
Nucleic Acids Research 49 (20): 11938-11958DOI: 10.1093/nar/gkab969
The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting
Zimmer MM, Kibe A, Rand U, Pekarek L, Ye L, Buck S, Smyth RP, Cicin-Sain L, Caliskan N (2021)
Nature Communications 12 (1): 7193DOI: 10.1038/s41467-021-27431-0
2020
The SARS-CoV-2 RNA-protein interactome in infected human cells
Schmidt N, Lareau CA, Keshishian H, Ganskih S, Schneider C, Hennig T, Melanson R, Werner S, Wei Y, Zimmer M, …, Bodem J, Munschauer M (2020)
Nature Microbiology 6 (3): 339-353DOI: 10.1038/s41564-020-00846-z
2019
Thermodynamic control of -1 programmed ribosomal frameshifting
Bock LV, Caliskan N, Korniy N, Peske F, Rodnina MV, Grubmüller H (2019)
Nature Communications 10: 4598DOI: 10.1038/s41467-019-12648-x
2018
Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting
Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K (2018)
Nucleic Acids Research 46 (16): 8079-8089DOI: 10.1093/nar/gky689
2017
Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA
Caliskan N, Wohlgemuth I, Korniy N, Pearson M, Peske F, Rodnina MV (2017)
Molecular Cell 66 (4): 558-567.e4DOI: 10.1016/j.molcel.2017.04.023
2016
Choreography of molecular movements during ribosome progression along mRNA
Belardinelli R, Sharma H, Caliskan N, Cunha CE, Peske F, Wintermeyer W, Rodnina MV (2016)
Nature Structural & Molecular Biology 23 (4): 342-8DOI: 10.1038/nsmb.3193
2015
Changed in translation: mRNA recoding by -1 programmed ribosomal frameshifting
Caliskan N, Peske F, Rodnina MV (2015)
Trends in Biochemical Sciences 40 (5): 265-74DOI: 10.1016/j.tibs.2015.03.006
2014
Programmed -1 frameshifting by kinetic partitioning during impeded translocation
Caliskan N, Katunin VI, Belardinelli R, Peske F, Rodnina MV (2014)
Cell 157 (7): 1619-31DOI: 10.1016/j.cell.2014.04.041