Jun Prof Neva Caliskan


Neva Caliskan studied molecular biology and genetics at the Middle East Technical University in Ankara (Turkey) and worked as a visiting scholar in 2005 at EMBL in Heidelberg. She received her Master's degree at the International Max Planck Research School for Molecular Biology (Göttingen) in 2009. After completing her PhD in 2013, she first worked as a postdoctoral fellow at the Department of Physical Biochemistry at the Max Planck Institute for Biophysical Chemistry and then as a project leader at the same institute from 2015-2017. Since January 2018 she has been heading the junior research group "Recoding Mechanisms in Infections" at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg. As of May 2018 she holds a junior professorship at the Faculty of Medicine of the University of Würzburg.


Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M, Caliskan N, Brown RJP, Steinmann E, Pietschmann T (2023)

Microbiology Spectrum (Online ahead of print)DOI: 10.1128/spectrum.01284-23

Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Pekarek L, Zimmer MM, Gribling-Burrer AS, Buck S, Smyth RP, Caliskan N (2023)

Nucleic Acids Research 51 (2): 728DOI: 10.1093/nar/gkac1184


Editorial: mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation

Kiss DL, Vasudevan D, Ho CK, Caliskan N (2022)

Frontiers in Molecular Biosciences 9: 947516DOI: 10.3389/fmolb.2022.947516

POTATO: Automated pipeline for batch analysis of optical tweezers data

Buck S, Pekarek L, Caliskan N (2022)

Biophysical Journal 121 (15): 2830-2839DOI: 10.1016/j.bpj.2022.06.030

Insights from structural studies of the cardiovirus 2A protein

Caliskan N, Hill CH (2022)

Bioscience Reports 42 (1): 2021040DOI: 10.1042/BSR20210406

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Pekarek L, Buck S, Caliskan N (2022)

Journal of Visualized Experiments (180)DOI: 10.3791/62589

Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

Riegger RJ, Caliskan N (2022)

Frontiers in Molecular Biosciences 9: 842261DOI: 10.3389/fmolb.2022.842261

Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging

Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP (2022)

Nature Structural & Molecular Biology 29 (4): 306-319DOI: 10.1038/s41594-022-00746-2

Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA

Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL (2022)

Nature Microbiology 7 (4): 530-541DOI: 10.1038/s41564-022-01074-3


Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Hill CH, Pekarek L, Napthine S, Kibe A, Firth AE, Graham SC, Caliskan N, Brierley I (2021)

Nature Communications 12 (1): 7166DOI: 10.1038/s41467-021-27400-7

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

Hill CH, Cook GM, Napthine S, Kibe A, Brown K, Caliskan N, Firth AE, Graham SC, Brierley I (2021)

Nucleic Acids Research 49 (20): 11938-11958DOI: 10.1093/nar/gkab969

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Zimmer MM, Kibe A, Rand U, Pekarek L, Ye L, Buck S, Smyth RP, Cicin-Sain L, Caliskan N (2021)

Nature Communications 12 (1): 7193DOI: 10.1038/s41467-021-27431-0


The SARS-CoV-2 RNA-protein interactome in infected human cells

Schmidt N, Lareau CA, Keshishian H, Ganskih S, Schneider C, Hennig T, Melanson R, Werner S, Wei Y, Zimmer M, …, Bodem J, Munschauer M (2020)

Nature Microbiology 6 (3): 339-353DOI: 10.1038/s41564-020-00846-z


Thermodynamic control of -1 programmed ribosomal frameshifting

Bock LV, Caliskan N, Korniy N, Peske F, Rodnina MV, Grubmüller H (2019)

Nature Communications 10: 4598DOI: 10.1038/s41467-019-12648-x


Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting

Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K (2018)

Nucleic Acids Research 46 (16): 8079-8089DOI: 10.1093/nar/gky689


Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA

Caliskan N, Wohlgemuth I, Korniy N, Pearson M, Peske F, Rodnina MV (2017)

Molecular Cell 66 (4): 558-567DOI: 10.1016/j.molcel.2017.04.023


Choreography of molecular movements during ribosome progression along mRNA

Belardinelli R, Sharma H, Caliskan N, Cunha CE, Peske F, Wintermeyer W, Rodnina MV (2016)

Nature Structural & Molecular Biology 23 (4): 342-8DOI: 10.1038/nsmb.3193


Changed in translation: mRNA recoding by -1 programmed ribosomal frameshifting

Caliskan N, Peske F, Rodnina MV (2015)

Trends in Biochemical Sciences 40 (5): 265-74DOI: 10.1016/j.tibs.2015.03.006


Programmed -1 frameshifting by kinetic partitioning during impeded translocation

Caliskan N, Katunin VI, Belardinelli R, Peske F, Rodnina MV (2014)

Cell 157 (7): 1619-31DOI: 10.1016/j.cell.2014.04.041