Prof Chase Beisel


Chase Beisel received his bachelors and doctoral degrees in chemical engineering, although he always maintained an interest in engineering biomolecules and biological systems. His doctoral work at the California Institute of Technology (Pasadena, California, USA) with Dr. Christina Smolke introduced him to the concept of RNA engineering. He then completed a two-year postdoctoral fellowship at the National Institutes of Health (Bethesda, Maryland, USA) under the direction of Dr. Gisela Storz exploring the natural properties of RNA regulators. He then began his faculty position in the department of chemical and biomolecular engineering at North Carolina State University (Raleigh, North Carolina, USA) in 2011 pursuing RNA-guided immune systems called CRISPR-Cas systems. He was promoted to Associate Professor with Tenure shortly before transitioning to the HIRI in 2018, where he focuses on applying RNA engineering to better understand, diagnose, and treat infectious disease.

His accomplishments have garnered consistent recognition, starting with graduate fellowships from the National Science Foundation and Department of Defense and a postdoctoral fellowship through the Life Science Research Foundation. Later, his independent research program has also been recognized with the CAREER Award from the US National Science Foundation, the Camille Dreyfus Teacher-Scholar Award, the Biotechnology & Bioengineering Daniel I.C. Wang Young Investigator Award, and the Bay Area Lyme Foundation Emerging Leader Award.


Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

Benz F, Camara-Wilpert S, Russel J, Wandera KG, Cepaite R, Ares-Arroyo M, Gomes-Filho JV, Englert F, Kuehn JA, Gloor S, …, Sørensen SJ, Pinilla-Redondo R (2024)

Cell Host & Microbe (Online ahead of print)DOI: 10.1016/j.chom.2024.04.016

Expanding the flexibility of base editing for high-throughput genetic screens in bacteria

Gawlitt S, Collins SP, Yu Y, Blackman SA, Barquist L, Beisel CL (2024)

Nucleic Acids Research (Online ahead of print)DOI: 10.1093/nar/gkae174

CRISPR-based screening of small RNA modulators of bile susceptibility in Bacteroides thetaiotaomicron

Prezza G, Liao C, Reichardt S, Beisel CL, Westermann AJ (2024)

Proceedings of the National Academy of Sciences of the United States of America 121 (6): 1096DOI: 10.1073/pnas.2311323121

A Hitchhiker's guide to CRISPR editing tools in bacteria : CRISPR can help unlock the bacterial world, but technical and regulatory barriers persist

Krink N, Nikel PI, Beisel CL (2024)

EMBO Reports (Online ahead of print)DOI: 10.1038/s44319-024-00086-w

An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between Klebsiella species

Almási ÉdH, Knischewski N, Osbelt L, Muthukumarasamy U, El Mouali Y, Vialetto E, Beisel CL, Strowig T (2024)

Journal of Bacteriology 206 (3): e0031723DOI: 10.1128/jb.00317-23

Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration

Yu Y, Gawlitt S, de Andrade E Sousa LB, Merdivan E, Piraud M, Beisel CL, Barquist L (2024)

Genome Biology 25 (1): 13DOI: 10.1186/s13059-023-03153-y


Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans reveals distinct anti-CRISPR proteins that block DNA degradation

Wimmer F, Englert F, Wandera KG, Alkhnbashi OS, Collins SP, Backofen R, Beisel CL (2023)

Nucleic Acids Research 52 (2): 769-783DOI: 10.1093/nar/gkad1097

Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint

Gawlitt S, Liao C, Achmedov T, Beisel CL (2023)

RNA Biology 20 (1): 666-680DOI: 10.1080/15476286.2023.2247247

For the CRISPR Fan(zor)atics: RNA-guided DNA endonucleases discovered in eukaryotes

Patinios C, Beisel CL (2023)

Molecular Cell 83 (17): 3046-3048DOI: 10.1016/j.molcel.2023.08.019

A predicted CRISPR-mediated symbiosis between uncultivated archaea

Esser SP, Rahlff J, Zhao W, Predl M, Plewka J, Sures K, Wimmer F, Lee J, Adam PS, McGonigle J, …, Zhang Y, Probst AJ (2023)

Nature Microbiology 8 (9): 1619-1633DOI: 10.1038/s41564-023-01439-2

Optimized metrics for orthogonal combinatorial CRISPR screens

Cetin R, Wegner M, Luwisch L, Saud S, Achmedov T, Süsser S, Vera-Guapi A, Müller K, Matthess Y, Quandt E, …, Beisel CL, Kaulich M (2023)

Scientific Reports 13 (1): 7405DOI: 10.1038/s41598-023-34597-8

Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria

Collias D, Vialetto E, Yu J, Co K, Almási ÉDH, Rüttiger AS, Achmedov T, Strowig T, Beisel CL (2023)

Nature Communications 14 (1): 680DOI: 10.1038/s41467-023-36283-9

RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2

Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW (2023)

Nature 613 (7944): 582-587DOI: 10.1038/s41586-022-05560-w

Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA

Dmytrenko O, Neumann GC, Hallmark T, Keiser DJ, Crowley VM, Vialetto E, Mougiakos I, Wandera KG, Domgaard H, Weber J, …, Jackson RN, Beisel CL (2023)

Nature 613 (7944): 588-594DOI: 10.1038/s41586-022-05559-3

RNA recording in single bacterial cells using reprogrammed tracrRNAs

Jiao C, Reckstadt C, König F, Homberger C, Yu J, Vogel J, Westermann AJ, Sharma CM, Beisel CL (2023)

Nature Biotechnology 41 (8): 1107-1116DOI: 10.1038/s41587-022-01604-8


The miniature CRISPR-Cas12m effector binds DNA to block transcription

Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, …, Beisel CL, van der Oost J (2022)

Molecular Cell 82 (23): 4487-4502.e7DOI: 10.1016/j.molcel.2022.11.003

Cell-Free Protein Synthesis from Exonuclease-Deficient Cellular Extracts Utilizing Linear DNA Templates

Sabeti Azad M, Cardoso Batista A, Faulon JL, Beisel CL, Bonnet J, Kushwaha M (2022)

Journal of Visualized Experiments (186): e64236DOI: 10.3791/64236

Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases

Wandera KG, Alkhnbashi OS, Bassett HVI, Mitrofanov A, Hauns S, Migur A, Backofen R, Beisel CL (2022)

Molecular Cell 82 (14): 2714-2726.e4DOI: 10.1016/j.molcel.2022.05.003

Reprogramming TracrRNAs for Multiplexed RNA Detection

Jiao C, Beisel CL (2022)

Methods in Molecular Biology 2518: 217-235DOI: 10.1007/978-1-0716-2421-0_13

A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13

Vialetto E, Yu Y, Collins SP, Wandera KG, Barquist L, Beisel CL (2022)

Cell Host & Microbe 3128 (22): 00273-6DOI: 10.1016/j.chom.2022.05.013

Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins

Gallo M, Vento JM, Joncour P, Quagliariello A, Maritan E, Silva-Soares NF, Battistolli M, Beisel CL, Martino ME (2022)

iScience 25 (6): 104357DOI: 10.1016/j.isci.2022.104357

Rapidly Characterizing CRISPR-Cas13 Nucleases Using Cell-Free Transcription-Translation Systems

Wandera KG, Beisel CL (2022)

Methods in Molecular Biology 2404: 135-153DOI: 10.1007/978-1-0716-1851-6_7

Differentially Optimized Cell-Free Buffer Enables Robust Expression from Unprotected Linear DNA in Exonuclease-Deficient Extracts

Batista AC, Levrier A, Soudier P, Voyvodic PL, Achmedov T, Reif-Trauttmansdorff T, DeVisch A, Cohen-Gonsaud M, Faulon JL, Beisel CL, Bonnet J, Kushwaha M (2022)

ACS Synthetic Biology 11 (2): 732-746DOI: 10.1021/acssynbio.1c00448

A TXTL-Based Assay to Rapidly Identify PAMs for CRISPR-Cas Systems with Multi-Protein Effector Complexes

Wimmer F, Englert F, Beisel CL (2022)

Methods in Molecular Biology 2433: 391-411DOI: 10.1007/978-1-0716-1998-8_24

Rapid cell-free characterization of multi-subunit CRISPR effectors and transposons

Wimmer F, Mougiakos I, Englert F, Beisel CL (2022)

Molecular Cell 82 (6): 1210-1224.e6DOI: 10.1016/j.molcel.2022.01.026

Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA

Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL (2022)

Nature Microbiology 7 (4): 530-541DOI: 10.1038/s41564-022-01074-3


Coupling smartphone and CRISPR–Cas12a for digital and multiplexed nucleic acid detection

Yu T, Zhang S, Matei R, Marx W, Beisel CL, Wei Q (2021)

American Institute of Chemical Engineers Journal 67 (12): 17399‐17405DOI: 10.1002/aic.17365

Illuminating the path to DNA repair

Gupta D, Beisel CL (2021)

Cell 184 (22): 5503-5505DOI: 10.1016/j.cell.2021.10.005

The tracrRNA in CRISPR Biology and Technologies

Liao C, Beisel CL (2021)

Annual Review of Genetics 55: 161-181DOI: 10.1146/annurev-genet-071719-022559

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Taxiarchi C, Beaghton A, Don NI, Kyrou K, Gribble M, Shittu D, Collins SP, Beisel CL, Galizi R, Crisanti A (2021)

Nature Communications 12 (1): 3977DOI: 10.1038/s41467-021-24214-5

CRISPR transposons on the move

Mougiakos I, Beisel CL (2021)

Cell Host & Microbe 29 (5): 675-677DOI: 10.1016/j.chom.2021.04.012

Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9

Jiao C, Sharma S, Dugar G, Peeck NL, Bischler T, Wimmer F, Yu Y, Barquist L, Schoen C, Kurzai O, Sharma CM, Beisel CL (2021)

Science 372 (6545): 941-948DOI: 10.1126/science.abe7106

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

Durmusoglu D, Al'Abri IS, Collins SP, Cheng J, Eroglu A, Beisel CL, Crook N (2021)

ACS Synthetic Biology 10 (5): 1039-1052DOI: 10.1021/acssynbio.0c00562

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR-Cas12a gRNA switch

Collins SP, Rostain W, Liao C, Beisel CL (2021)

Nucleic Acids Research 49 (5): 2985-2999DOI: 10.1093/nar/gkab100

A Code of Ethics for Gene Drive Research

Annas GJ, Beisel CL, Clement K, Crisanti A, Francis S, Galardini M, Galizi R, Grünewald J, Immobile G, Khalil AS, …, Taxiarchi C, Joung JK (2021)

The CRISPR Journal 4 (1): 19-24DOI: 10.1089/crispr.2020.0096

CRISPR technologies and the search for the PAM-free nuclease

Collias D, Beisel CL (2021)

Nature Communications 12 (1): 555DOI: 10.1038/s41467-020-20633-y


Rapid Testing of CRISPR Nucleases and Guide RNAs in an E. coli Cell-Free Transcription-Translation System

Marshall R, Beisel CL, Noireaux V (2020)

STAR Protocols 1 (1): 100003DOI: 10.1016/j.xpro.2019.100003

A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9

Collias D, Leenay RT, Slotkowski RA, Zuo Z, Collins SP, McGirr BA, Liu J, Beisel CL (2020)

Science Advances 6 (29): eabb4054DOI: 10.1126/sciadv.abb4054

Your Base Editor Might Be Flirting with Single (Stranded) DNA: Faithful On-Target CRISPR Base Editing without Promiscuous Deamination

Collins SP, Beisel CL (2020)

Molecular Cell 79 (5): 703-704DOI: 10.1016/j.molcel.2020.07.030

Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs

Jacobsen T, Ttofali F, Liao C, Manchalu S, Gray BN, Beisel CL (2020)

Nucleic Acids Research 48 (10): 5624-5638DOI: 10.1093/nar/gkaa272

Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

Jacobsen T, Yi G, Al Asafen H, Jermusyk AA, Beisel CL, Reeves GT (2020)

PLOS One 15 (4): e0232046DOI: 10.1371/journal.pone.0232046

Competitive exclusion is a major bioprotective mechanism of lactobacilli against fungal spoilage in fermented milk products

Siedler S, Rau MH, Bidstrup S, Vento JM, Aunsbjerg SD, Bosma EF, McNair LM, Beisel CL, Neves AR (2020)

Applied and Environmental Microbiology 86 (7): e02312-19DOI: 10.1128/AEM.02312-19

Methods for characterizing, applying, and teaching CRISPR-Cas systems

Beisel CL (2020)

Methods 172: 1-2DOI: 10.1016/j.ymeth.2020.01.004

CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers

Wimmer F, Beisel CL (2020)

Frontiers in Microbiology 10: 3078DOI: 10.3389/fmicb.2019.03078


An educational module to explore CRISPR technologies with a cell-free transcription-translation system

Collias D, Marshall R, Collins SP, Beisel CL, Noireaux V (2019)

Synthetic Biology 4 (1): 156DOI: 10.1093/synbio/ysz005

Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells

Pickar-Oliver A, Black JB, Lewis MM, Mutchnick KJ, Klann TS, Gilcrest KA, Sitton MJ, Nelson CE, Barrera A, Bartelt LC, …, Barrangou R, Gersbach CA (2019)

Nature Biotechnology 37 (12): 1493-1501DOI: 10.1038/s41587-019-0235-7

CRATES: A one-step assembly method for Class 2 CRISPR arrays

Liao C, Slotkowski RA, Beisel CL (2019)

Methods In Enzymology 629: 493-511DOI: 10.1016/bs.mie.2019.04.011

Barriers to genome editing with CRISPR in bacteria

Vento JM, Crook N, Beisel CL (2019)

Journal of Industrial Microbiology & Biotechnology 46 (9-10): 1327-1341DOI: 10.1007/s10295-019-02195-1

Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis

Liao C, Ttofali F, Slotkowski RA, Denny SR, Cecil TD, Leenay RT, Keung AJ, Beisel CL (2019)

Nature Communications 10: 2948DOI: 10.1038/s41467-019-10747-3

Characterization of the all-E. coli transcription-translation system myTXTL by mass spectrometry

Garenne D, Beisel CL, Noireaux V (2019)

Rapid Communications In Mass Spectrometry 33 (11): 1036-1048DOI: 10.1002/rcm.8438

Distinct timescales of RNA regulators enable the construction of a genetic pulse generator

Westbrook A, Tang X, Marshall R, Maxwell CS, Chappell J, Agrawal DK, Dunlop MJ, Noireaux V, Beisel CL, Lucks J, Franco E (2019)

Biotechnology and Bioengineering 116 (5): 1139-1151DOI: 10.1002/bit.26918

An enhanced assay to characterize anti-CRISPR proteins using a cell-free transcription-translation system

Wandera KG, Collins SP, Wimmer F, Marshall R, Noireaux V, Beisel CL (2019)

Methods 172: 42-50DOI: 10.1016/j.ymeth.2019.05.014

The Acidaminococcus sp. Cas12a nuclease recognizes GTTV and GCTV as non-canonical PAMs

Jacobsen T, Liao C, Beisel CL (2019)

FEMS Microbiology Letters 366 (8): pii: fnz085DOI: 10.1093/femsle/fnz085


Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis

Martino ME, Joncour P, Leenay R, Gervais H, Shah M, Hughes S, Gillet B, Beisel CL, Leulier F (2018)

Cell Host & Microbe 24 (1): 109-119.e6DOI: 10.1016/j.chom.2018.06.001

CRISPR tool puts RNA on the record

Beisel CL (2018)

Nature 562 (7727): 347-349DOI: 10.1038/d41586-018-06869-1

Advances in CRISPR Technologies for Microbial Strain Engineering

Alper HS, Beisel CL (2018)

Biotechnology Journal 13 (9): e1800460DOI: 10.1002/biot.201800460

Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications

Bober JR, Beisel CL, Nair NU (2018)

Annual Review of Biomedical Engineering 20: 277-300DOI: 10.1146/annurev-bioeng-062117-121019

Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression

Agrawal DK, Tang X, Westbrook A, Marshall R, Maxwell CS, Lucks J, Noireaux V, Beisel CL, Dunlop MJ, Franco E (2018)

ACS Synthetic Biology 7 (5): 1219-1228DOI: 10.1021/acssynbio.8b00040

A detailed cell-free transcription-translation-based assay to decipher CRISPR protospacer-adjacent motifs

Maxwell CS, Jacobsen T, Marshall R, Noireaux V, Beisel CL (2018)

Methods 143: 48-57DOI: 10.1016/j.ymeth.2018.02.016

Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods

Leenay RT, Vento JM, Shah M, Martino ME, Leulier F, Beisel CL (2018)

Biotechnology Journal 14 (3): e1700583DOI: 10.1002/biot.201700583

The Francisella novicida Cas12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays

Liao C, Slotkowski RA, Achmedov T, Beisel CL (2018)

RNA Biology 16 (4): 404-412DOI: 10.1080/15476286.2018.1526537

Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System

Marshall R, Maxwell CS, Collins SP, Jacobsen T, Luo ML, Begemann MB, Gray BN, January E, Singer A, He Y, Beisel CL, Noireaux V (2018)

Molecular Cell 69 (1): 146-157.e3DOI: 10.1016/j.molcel.2017.12.007

CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9

Dugar G, Leenay RT, Eisenbart SK, Bischler T, Aul BU, Beisel CL, Sharma CM (2018)

Molecular Cell 69 (5): 893-905.e7DOI: 10.1016/j.molcel.2018.01.032


What Is the Role of Circuit Design in the Advancement of Synthetic Biology? Part 1

Beisel CL (2017)

Cell Systems 4 (4): 370-372DOI: 10.1016/j.cels.2017.04.003

Deciphering, Communicating, and Engineering the CRISPR PAM

Leenay RT, Beisel CL (2017)

Journal of Molecular Biology 429 (2): 177-191DOI: 10.1016/j.jmb.2016.11.024

Toward a genetic tool development pipeline for host-associated bacteria

Waller MC, Bober JR, Nair NU, Beisel CL (2017)

Current Opinion in Microbiology 38: 156-164DOI: 10.1016/j.mib.2017.05.006

Short DNA containing χ sites enhances DNA stability and gene expression in E. coli cell-free transcription-translation systems

Marshall R, Maxwell CS, Collins SP, Beisel CL, Noireaux V (2017)

Biotechnology and Bioengineering 114 (9): 2137-41DOI: 10.1002/bit.26333

Advancing the design and delivery of CRISPR antimicrobials

Fagen JR, Collias D, Singh AK, Beisel CL (2017)

Current Opinion in Biomedical Engineering 4: 57-64DOI: 10.1016/j.cobme.2017.10.001


SBE Supplement: Synthetic Biology – Engineering Genes with CRISPR-Cas9

Luo ML, Beisel CL (2016)

American Institute of Chemical Engineers

Synthetic Biology - Engineering Genes with CRISPR-Cas9

Luo ML, Beisel CL (2016)

CEP Magazine September

Rethinking the Hierarchy of Sugar Utilization in Bacteria

Beisel CL, Afroz T (2016)

Journal of Bacteriology 198 (3): 374-376DOI: 10.1128/JB.00890-15

Current and future prospects for CRISPR-based tools in bacteria

Luo ML, Leenay RT, Beisel CL (2016)

Biotechnology and Bioengineering 113 (5): 930-43DOI: 10.1002/bit.25851

The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers

Luo ML, Jackson RN, Denny SR, Tokmina-Lukaszewska M, Maksimchuk KR, Lin W, Bothner B, Wiedenheft B, Beisel CL (2016)

Nucleic Acids Research 44 (15): 7385-94DOI: 10.1093/nar/gkw421

Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems

Leenay RT, Maksimchuk KR, Slotkowski RA, Agrawal RN, Gomaa AA, Briner AE, Barrangou R, Beisel CL (2016)

Molecular Cell 62 (1): 137-47DOI: 10.1016/j.molcel.2016.02.031


Integrative, ligand-responsive microRNAs

Smolke CD, Beisel CL (2015)

Patent (US9145555B2)

Trade-offs in engineering sugar utilization pathways for titratable control

Afroz T, Biliouris K, Boykin KE, Kaznessis Y, Beisel CL (2015)

ACS Synthetic Biology 4 (2): 141-9DOI: 10.1021/sb400162z

Impact of Residual Inducer on Titratable Expression Systems

Afroz T, Luo ML, Beisel CL (2015)

PLOS One 10 (9): e0137421DOI: 10.1371/journal.pone.0137421

Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Sun W, Ji W, Hall JM, Hu Q, Wang C, Beisel CL, Gu Z (2015)

Angewandte Chemie International Edition 54 (41): 12029-33DOI: 10.1002/anie.201506030

Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression

Luo ML, Mullis AS, Leenay RT, Beisel CL (2015)

Nucleic Acids Research 43 (1): 674-81DOI: 10.1093/nar/gku971


Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing

Beisel CL, Bloom RJ, Smolke CD (2014)

In: Artificial Riboswitches (ed Ogawa A), Methods Mol Biol 1111: 259-67DOI: 10.1007/978-1-62703-755-6_19

A CRISPR design for next-generation antimicrobials

Beisel CL, Gomaa AA, Barrangou R (2014)

Genome Biology 15 (11): 516DOI: 10.1186/s13059-014-0516-x

Bacterial sugar utilization gives rise to distinct single-cell behaviours

Afroz T, Biliouris K, Kaznessis Y, Beisel CL (2014)

Molecular Microbiology 93 (6): 1093-1103DOI: 10.1111/mmi.12695

Guide RNA functional modules direct Cas9 activity and orthogonality

Briner AE, Donohoue PD, Gomaa AA, Selle K, Slorach EM, Nye CH, Haurwitz RE, Beisel CL, May AP, Barrangou R (2014)

Molecular Cell 56 (2): 333-339DOI: 10.1016/j.molcel.2014.09.019

Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems

Gomaa AA, Klumpe HE, Luo ML, Selle K, Barrangou R, Beisel CL (2014)

mBio 5 (1): e00928-13DOI: 10.1128/mBio.00928-13


Modular polynucleotides for ligand-controlled regulatory systems

Smolke CD, Win MN, Beisel CL (2013)

Patent (US8367815B2)

Understanding and exploiting feedback in synthetic biology

Afroz T, Beisel CL (2013)

Chemical Engineering Science 103: 79-90DOI: 10.1016/j.ces.2013.02.017


Multiple factors dictate target selection by Hfq-binding small RNAs

Beisel CL, Updegrove TB, Janson BJ, Storz G (2012)

The EMBO Journal 31 (8): 1961-74DOI: 10.1038/emboj.2012.52


Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD (2011)

Nucleic Acids Research 39 (7): 2981-94DOI: 10.1093/nar/gkq954

The base pairing RNA Spot 42 participates in a multi-output feedforward loop to help enact catabolite repression in Escherichia coli

Beisel CL, Storz G (2011)

Molecular Cell 41 (3): 286-97DOI: 10.1016/j.molcel.2010.12.027

Discriminating tastes: physiological contributions of the Hfq-binding small RNA Spot 42 to catabolite repression

Beisel CL, Storz G (2011)

RNA Biology 8 (5): 766-70DOI: 10.4161/rna.8.5.16024


Base pairing small RNAs and their roles in global regulatory networks

Beisel CL, Storz G (2010)

FEMS Microbiology Reviews 34 (5): 866-82DOI: 10.1111/j.1574-6976.2010.00241.x


Synthetic control of a fitness tradeoff in yeast nitrogen metabolism

Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD (2009)

Journal of Biological Engineering 3: 1DOI: 10.1186/1754-1611-3-1

Design Principles for Riboswitch Function

Beisel CL, Smolke CD (2009)

PLOS Computational Biology 5 (4): e1000363DOI: 10.1371/journal.pcbi.1000363


Model-guided design of ligand-regulated RNAi for programmable control of gene expression

Beisel CL, Bayer TS, Hoff KG, Smolke CD (2008)

Molecular Systems Biology 4: 224DOI: 10.1038/msb.2008.62


Conformational analysis of gossypol and its derivatives by molecular mechanics

Beisel CL, Dowd MK, Reilly PJ (2005)

Journal Of Molecular Structure: Computational and Theoretical Chemistry 730 (1-3): 51-58DOI: 10.1016/j.theochem.2005.05.010


Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients

Judice TN, Nelson NC, Beisel CL, Delimont DC, Fritzsch B, Beisel KW (2002)

Brain Research Protocols 9 (1): 65-76DOI: 10.1016/S1385-299X(01)00138-6