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“We are pioneers”
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understand why pathogens escape therapy, we are studying their RNA. And we are developing novel, programmable RNA-based antibiotics. You have mentioned that the researchers at the HIRI are also technological
she joined the Vogel lab at the Helmholtz Institute Würzburg (Germany) as a PhD student to study programmable antibiotics based on antisense oligonucleotides (ASOs) as part of the graduate program “RNAmed
An RNA biology perspective on species-specific programmable RNA antibiotics
Publication
Vogel J
(2020)
Molecular Microbiology, 113, 3, 550-559, 10.1111/mmi.14476, 32185839
Molecular Microbiology, 113, 3, 550-559, 10.1111/mmi.14476, 32185839
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
Publication
Luo ML,
Mullis AS,
Leenay RT,
Beisel CL
(2015)
Nucleic Acids Research, 43, 1, 674-81, 10.1093/nar/gku971, 25326321
Nucleic Acids Research, 43, 1, 674-81, 10.1093/nar/gku971, 25326321
Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems
Publication
Gomaa AA,
Klumpe HE,
Luo ML,
Selle K,
Barrangou R,
Beisel CL
(2014)
mBio, 5, 1, e00928-13, 10.1128/mBio.00928-13, 24473129
mBio, 5, 1, e00928-13, 10.1128/mBio.00928-13, 24473129
Model-guided design of ligand-regulated RNAi for programmable control of gene expression
Publication
Beisel CL,
Bayer TS,
Hoff KG,
Smolke CD
(2008)
Molecular Systems Biology, 4, 224, 10.1038/msb.2008.62, 18956013
Molecular Systems Biology, 4, 224, 10.1038/msb.2008.62, 18956013