Dr Redmond Smyth


Redmond Smyth carried out his undergraduate degree in Natural Sciences at the University of Cambridge (UK), specializing in Virology and Immunology. He then moved to the Burnet Institute, Melbourne (Australia) for his PhD, where he investigated the mechanisms of HIV-1 genetic diversity in its natural target cells. His PhD research pointed to the importance of RNA structure in regulating viral infection processes, which is why he then moved to Strasbourg (France) for his post-doctoral research to train as an RNA biochemist. Here, he worked on understanding the mechanisms leading to the incorporation of the HIV-1 genomic RNA into viral particles. In 2015, he was recruited to the CNRS as a chargé de recherché (CR2), and in 2018, with support from the Helmholtz Association, he started his own research group at the Helmholtz Institute for RNA-based Infection Research (HIRI).


Recruitment of multi-segment genomic RNAs by Bluetongue virus requires a preformed RNA network

Sung PY, Phelan JE, Luo D, Kulasegaran-Shylini R, Bohn P, Smyth RP, Roy P (2024)P., Roy P (2024)

Nucleic Acids Research (Online ahead of print)DOI: 10.1093/nar/gkae404

Sequencing accuracy and systematic errors of nanopore direct RNA sequencing

Liu-Wei W, van der Toorn W, Bohn P, Hölzer M, Smyth RP, von Kleist M (2024)

BMC Genomics 25 (1): 528DOI: 10.1186/s12864-024-10440-w

Isoform-specific RNA structure determination using Nano-DMS-MaP

Gribling-Burrer AS, Bohn P, Smyth RP (2024)

Nature Protocols (Online ahead of print)DOI: 10.1038/s41596-024-00959-3


SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, …, Erhard F, Munschauer M (2023)

Cell 186 (22): 4834-4850.e23DOI: 10.1016/j.cell.2023.09.002

Advanced fluorescence microscopy in respiratory virus cell biology

Xie E, Ahmad S, Smyth RP, Sieben C (2023)

Advances in Virus Research 116: 123-172DOI: 10.1016/bs.aivir.2023.05.002

Sequential disruption of SPLASH-identified vRNA-vRNA interactions challenges their role in influenza A virus genome packaging

Jakob C, Lovate GL, Desirò D, Gießler L, Smyth RP, Marquet R, Lamkiewicz K, Marz M, Schwemmle M, Bolte H (2023)

Nucleic Acids Research 51 (12): 6479-6494DOI: 10.1093/nar/gkad442

Nano-DMS-MaP allows isoform-specific RNA structure determination

Bohn P, Gribling-Burrer AS, Ambi UB, Smyth RP (2023)

Nature Methods 20 (6): 849-859DOI: 10.1038/s41592-023-01862-7

Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Pekarek L, Zimmer MM, Gribling-Burrer AS, Buck S, Smyth RP, Caliskan N (2023)

Nucleic Acids Research 51 (2): 728–743DOI: 10.1093/nar/gkac1184