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Prof Chase Beisel

About

Chase Beisel received his bachelors and doctoral degrees in chemical engineering, although he always maintained an interest in engineering biomolecules and biological systems. His doctoral work at the California Institute of Technology (Pasadena, California, USA) with Dr. Christina Smolke introduced him to the concept of RNA engineering. He then completed a two-year postdoctoral fellowship at the National Institutes of Health (Bethesda, Maryland, USA) under the direction of Dr. Gisela Storz exploring the natural properties of RNA regulators. He then began his faculty position in the department of chemical and biomolecular engineering at North Carolina State University (Raleigh, North Carolina, USA) in 2011 pursuing RNA-guided immune systems called CRISPR-Cas systems. He was promoted to Associate Professor with Tenure shortly before transitioning to the HIRI in 2018, where he focuses on applying RNA engineering to better understand, diagnose, and treat infectious disease.

His accomplishments have garnered consistent recognition, starting with graduate fellowships from the National Science Foundation and Department of Defense and a postdoctoral fellowship through the Life Science Research Foundation. Later, his independent research program has also been recognized with the CAREER Award from the US National Science Foundation, the Camille Dreyfus Teacher-Scholar Award, the Biotechnology & Bioengineering Daniel I.C. Wang Young Investigator Award, and the Bay Area Lyme Foundation Emerging Leader Award.


2022

CRISPR memories in single cells

Sparmann A, Beisel CL (2022)

Molecular Systems Biology 18 (4): 11011DOI: 10.15252/msb.202211011

Rapidly Characterizing CRISPR-Cas13 Nucleases Using Cell-Free Transcription-Translation Systems

Wandera KG, Beisel CL (2022)

Methods in Molecular Biology 2404: 135-153DOI: 10.1007/978-1-0716-1851-6_7

Differentially Optimized Cell-Free Buffer Enables Robust Expression from Unprotected Linear DNA in Exonuclease-Deficient Extracts

Batista AC, Levrier A, Soudier P, Voyvodic PL, Achmedov T, Reif-Trauttmansdorff T, DeVisch A, Cohen-Gonsaud M, Faulon JL, Beisel CL, Bonnet J, Kushwaha M (2022)

ACS Synthetic Biology 11 (2): 732-746DOI: 10.1021/acssynbio.1c00448

A TXTL-Based Assay to Rapidly Identify PAMs for CRISPR-Cas Systems with Multi-Protein Effector Complexes

Wimmer F, Englert F, Beisel CL (2022)

Methods in Molecular Biology 2433: 391-411DOI: 10.1007/978-1-0716-1998-8_24

Rapid cell-free characterization of multi-subunit CRISPR effectors and transposons

Wimmer F, Mougiakos I, Englert F, Beisel CL (2022)

Molecular Cell 82 (6): 1210-1224DOI: 10.1016/j.molcel.2022.01.026

Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA

Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL (2022)

Nature Microbiology 7 (4): 530-541DOI: 10.1038/s41564-022-01074-3

2021

Coupling smartphone and CRISPR–Cas12a for digital and multiplexed nucleic acid detection

Yu T, Zhang S, Matei R, Marx W, Beisel CL, Wei Q (2021)

American Institute of Chemical Engineers Journal 67 (12): 17399DOI: 10.1002/aic.17365

Illuminating the path to DNA repair

Gupta D, Beisel CL (2021)

Cell 184 (22): 5503-5505DOI: 10.1016/j.cell.2021.10.005

The tracrRNA in CRISPR Biology and Technologies

Liao C, Beisel CL (2021)

Annual Review of Genetics 55: 161-181DOI: 10.1146/annurev-genet-071719-022559

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Taxiarchi C, Beaghton A, Don NI, Kyrou K, Gribble M, Shittu D, Collins SP, Beisel CL, Galizi R, Crisanti A (2021)

Nature Communications 12 (1): 3977DOI: 10.1038/s41467-021-24214-5

CRISPR transposons on the move

Mougiakos I, Beisel CL (2021)

Cell Host & Microbe 29 (5): 675-677DOI: 10.1016/j.chom.2021.04.012

Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9

Jiao C, Sharma S, Dugar G, Peeck NL, Bischler T, Wimmer F, Yu Y, Barquist L, Schoen C, Kurzai O, Sharma CM, Beisel CL (2021)

Science 372 (6545): 941-948DOI: 10.1126/science.abe7106

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

Durmusoglu D, Al'Abri IS, Collins SP, Cheng J, Eroglu A, Beisel CL, Crook N (2021)

ACS Synthetic Biology 10 (5): 1039-1052DOI: 10.1021/acssynbio.0c00562

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR-Cas12a gRNA switch

Collins SP, Rostain W, Liao C, Beisel CL (2021)

Nucleic Acids Research 49 (5): 2985-2999DOI: 10.1093/nar/gkab100

A Code of Ethics for Gene Drive Research

Annas GJ, Beisel CL, Clement K, Crisanti A, Francis S, Galardini M, Galizi R, Grünewald J, Immobile G, Khalil AS, …, Taxiarchi C, Joung JK (2021)

The CRISPR journal 4 (1): 19-24DOI: 10.1089/crispr.2020.0096

CRISPR technologies and the search for the PAM-free nuclease

Collias D, Beisel CL (2021)

Nature Communications 12: 555DOI: 10.1038/s41467-020-20633-y