EN | DE

Prof. Antoine-Emmanuel Saliba

Über

Antoine-Emmanuel Saliba studierte Bioverfahrenstechnik am Institut National des Sciences Appliqués (INSA) in Toulouse (Frankreich) und promovierte in der Forschungsgruppe von Jean-Louis Viovy am Institut Curie in Paris. Er setzte mikrofluidbasierte Systeme zur Sortierung und Analyse seltener Subpopulationen von Krebszellen ein. Anschließend arbeitete er als Stipendiat der interdisziplinären Postdoc Initiative (EIPOD) des Europäischen Laboratoriums für Molekularbiologie (EMBL) in Heidelberg. Dort war er an der Entwicklung innovativer systembiologischer Ansätze zur Analyse von Protein-Lipid-Wechselwirkungen beteiligt. Als Postdoc kam er anschließend ans Labor von Jörg Vogel in Würzburg und etablierte dort die Technologie der Einzelzell-RNA-Sequenzierung. Mit deren Hilfe verfolgte er beispielsweise das Schicksal einzelner Zellen während einer Infektion mit Salmonella enterica. Seit 2017 leitet er die Gruppe Einzelzellanalyse am HIRI. Er ist seit 2023 außerdem Professor (W2) an der Medizinischen Fakultät der Universität Würzburg.


2024

Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis

Kumar N, Prakash PG, Wentland C, Kurian SM, Jethva G, Brinkmann V, Mollenkopf HJ, Krammer T, Toussaint C, Saliba AE, …, Gurumurthy RK, Chumduri C (2024)

Nature Communications 15 (1): 3064DOI: 10.1038/s41467-024-47173-z

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Costa B, Becker J, Krammer T, Mulenge F, Durán V, Pavlou A, Gern OL, Chu X, Li Y, Cicin-Šain L, …, Erhard F, Kalinke U (2024)

Nature Communications 15 (1): 1745DOI: 10.1038/s41467-024-45614-3

Sequential Antigen-loss and Branching Evolution in Lymphoma after CD19- and CD20-Targeted T-cell Redirecting Therapy

Duell J, Leipold AM, Appenzeller S, Fuhr V, Rauert-Wunderlich H, Da Vià MC, Dietrich O, Toussaint C, Imdahl F, Eisele F, …, Saliba AE, Rasche L (2024)

Blood 143 (8): 685-696DOI: 10.1182/blood.2023021672

2023

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson's disease

McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, …, Volkmann J, Ip CW (2023)

Nature Communications 14 (1): 7529DOI: 10.1038/s41467-023-43224-z

Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms

Reuter C, Hauf L, Imdahl F, Sen R, Vafadarnejad E, Fey P, Finger T, Jones NG, Walles H, Barquist L, …, Groeber-Becker F, Engstler M (2023)

Nature Communications 14 (1): 7660DOI: 10.1038/s41467-023-43437-2

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F, Saliba AE, Coleman M, …, Simons M, Martini R (2023)

Nature Communications 14 (1): 6911DOI: 10.1038/s41467-023-42570-2

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Zhang Y, Vandestienne M, Lavillegrand JR, Joffre J, Santos-Zas I, Lavelle A, Zhong X, Le Goff W, Guérin M, Al-Rifai R, …, Sokol H, Ait-Oufella H (2023)

Nature Communications 14 (1): 4622DOI: 10.1038/s41467-023-40216-x

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

Eyraud E, Maurat E, Sac-Epée JM, Henrot P, Zysman M, Esteves P, Trian T, Dupuy JW, Leipold A, Saliba AE, …, Berger P, Dupin I (2023)

eLife 12: RP85875DOI: 10.7554/eLife.85875

Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

Ugur M, Labios RJ, Fenton C, Knöpper K, Jobin K, Imdahl F, Golda G, Hoh K, Grafen A, Kaisho T, …, Bajénoff M, Kastenmüller W (2023)

Immunity 58 (8): 1778-1793.e10DOI: 10.1016/j.immuni.2023.06.020

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice

Abdelwahab T, Stadler D, Knöpper K, Arampatzi P, Saliba AE, Kastenmüller W, Martini R, Groh J (2023)

iScience 26 (5): 106698DOI: 10.1016/j.isci.2023.106698

An interferon gamma response signature links myocardial aging and immunosenescence

Ashour D, Rebs S, Arampatzi P, Saliba AE, Dudek J, Schulz R, Hofmann U, Frantz S, Cochain C, Streckfuß-Bömeke K, Ramos GC (2023)

Cardiovascular Research 119 (14): 2458-2468DOI: 10.1093/cvr/cvad068

Advancing massive transcriptional profiling of single bacteria

Saliba AE (2023)

Cell Reports Methods 3 (2): 100416DOI: 10.1016/j.crmeth.2023.100416

A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection

Däullary T, Imdahl F, Dietrich O, Hepp L, Krammer T, Fey C, Neuhaus W, Metzger M, Vogel J, Westermann AJ, Saliba AE, Zdzieblo D (2023)

Gut Microbes 15 (1): 2186109DOI: 10.1080/19490976.2023.2186109

Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

Leipold AM, Werner RA, Düll J, Jung P, John M, Stanojkovska E, Zhou X, Hornburger H, Ruckdeschel A, Dietrich O, …, Saliba AE, Rasche L (2023)

Leukemia 37 (3): 650-658DOI: 10.1038/s41375-023-01824-0

Myocardial Milieu Favors Local Differentiation of Regulatory T Cells

Delgobo M, Weiß E, ElDin Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer PP, …, Frantz S, Campos Ramos G (2023)

Circulation Research 132 (5): 565-582DOI: 10.1161/CIRCRESAHA.122.322183

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, …, Schulte LN, Li Y (2023)

Cell Genomics 3 (2): 100232DOI: 10.1016/j.xgen.2022.100232

A MATQ-seq-Based Protocol for Single-Cell RNA-seq in Bacteria

Homberger C, Saliba AE, Vogel J (2023)

Methods in Molecular Biology 2584: 105-121DOI: 10.1007/978-1-0716-2756-3_4

Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis

Zernecke A, Erhard F, Weinberger T, Schulz C, Ley K, Saliba AE, Cochain C (2023)

Cardiovascular Research 119 (8): 1676-1689DOI: 10.1093/cvr/cvac161

Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction

Rizzo G, Gropper J, Piollet M, Vafadarnejad E, Rizakou A, Bandi SR, Arampatzi P, Krammer T, DiFabion N, Dietrich O, …, Saliba AE, Cochain C (2023)

Cardiovascular Research 119 (3): 772-785DOI: 10.1093/cvr/cvac113

Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles

Akbar N, Braithwaite AT, Corr EM, Koelwyn GJ, van Solingen C, Cochain C, Saliba AE, Corbin A, Pezzolla D, Møller Jørgensen M, …, Melling GE, Shanmuganathan M (2023)

Cardiovascular Research 119 (1): 236-251DOI: 10.1093/cvr/cvac012