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[Translate to English:] Portrait von Prof. Fabian Leendertz

Leendertz: "Human health cannot be viewed in isolation"

New Helmholtz institute conducts research at the interface of human health, animal health and the environment

In Greifswald wurde heute das Helmholtz-Institut für One Health (HIOH) feierlich gegründet. Das HIOH ist ein neues Institut des Braunschweiger Helmholtz-Zentrums für Infektionsforschung (HZI), das gemeinsam mit der Universität Greifswald, der Universitätsmedizin Greifswald und dem Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit (FLI) als lokale Gründungspartner aufgebaut wird. Gründungsdirektor ist der Veterinärmediziner und Mikrobiologe Prof. Fabian Leendertz. Die Forschung am neuen Institut konzentriert sich auf die Bedrohungen durch das Auftreten neuartiger und die Veränderung bekannter Krankheitserreger, einschließlich deren antimikrobieller Resistenzen (AMR) gegen gängige Medikamente und Impfstoffe.

 

Der Kontakt zwischen Menschen und Tieren wird zunehmend enger. Gründe dafür sind die wachsende Weltbevölkerung, das immer tiefere Eindringen der Menschen in natürliche Lebensräume, die Jagd auf Wildtiere sowie die intensive Viehhaltung und Landwirtschaft. Kombiniert mit Globalisierung, Klimawandel und der erhöhten Mobilität der Menschen sind dies die Hauptursachen für den Ausbruch und die rasche Ausbreitung von Infektionen – das Coronavirus SARS-CoV-2 ist nur ein Beispiel dafür. Neu auftretende oder veränderte Krankheitserreger können sich in kürzester Zeit global verbreiten, Artgrenzen überwinden und zudem Multiresistenzen entwickeln.

„Die menschliche Gesundheit lässt sich nicht mehr isoliert betrachten. Wir haben in den vergangenen Jahren lernen müssen, dass sie eng mit der Gesundheit von Tieren, der Umwelt und auch der ökologischen Diversität verwoben ist“, sagt Fabian Leendertz, Gründungsdirektor des neuen Helmholtz-Instituts für One Health (HIOH) und Professor für One Health an der Universität Greifswald. Das One Health-Konzept ist ein interdisziplinärer Forschungsansatz, der genau an diesen Schnittstellen ansetzt. Eine integrierte Überwachung und Verbesserung der Gesundheit von Mensch und Tier sowie von Umwelt- und Klimafaktoren soll ganzheitliche Ansätze zur Bewältigung der gesundheitlichen Herausforderungen durch Infektionskrankheiten liefern.

[Translate to English:] Portrait von Prof. Fabian Leendertz

[Translate to English:] Fabian Leendertz, Gründungsdirektor des neuen Helmholtz-Instituts für One Health (HIOH) und Professor für One Health an der Universität Greifswald. © Universität Greifswald / Stefan Sauer

One Health Concept

One Health Concept
One Health Conzept. © HIOH / UNA[H]RT DESIGN

"Our One Health concept was reviewed very positively in November, now it has to prove itself," says Leendertz. "So I am very happy that with the new Helmholtz Institute for One Health we have the opportunity to build our research on the principles of One Health and include all disciplines from which the research approach can benefit." The HIOH is being established as a new site of the Helmholtz Centre for Infection Research (HZI) and will primarily use the HZI's expertise in epidemiology, drug and vaccine research. Fabian Leendertz is convinced that the research location Greifswald offers very good conditions for this with the University of Greifswald, which covers a traditionally broad expertise in ecology and zoology, but can also provide input from experienced specialists for certain pathogens as well as from completely different disciplines. Greifswald University Medicine is an important partner, for example, for cohort studies in which people are monitored over long periods of time and health data is collected. Finally, the Friedrich-Loeffler-Institut covers the focus on animal health and offers a unique infrastructure with laboratories up to the highest security level (S4). "Embedding the Helmholtz Institute for One Health in the Helmholtz Association also offers many points of connection to other Helmholtz centres in health, environmental and climate research, so that the HIOH can increase the degree of networking within the community even more," says Leendertz.

 

Especially for our research approach, close collaboration and continuous cross-cutting data analysis is crucial to be able to quickly and efficiently bring results into application.

FABIAN LEENDERTZ, FOUNDING DIRECTOR OF THE NEW HELMHOLTZ INSTITUTE FOR ONE HEALTH (HIOH) AND PROFESSOR OF ONE HEALTH AT THE UNIVERSITY OF GREIFSWALD

Modellregionen der One Health Surveillance.

Modellregionen der One Health Surveillance.
Modellregionen der One Health Surveillance. © HIOH / UNA[H]RT DESIGN © HIOH / UNA[H]RT DESIGN

"With the establishment of the Helmholtz Institute for One Health, the HZI is consistently pursuing its interdisciplinary, systemic and translational research mission," says Prof Dirk Heinz, Scientific Director of the Helmholtz Centre for Infection Research. "This is the only way we can meet future challenges such as novel pandemics, the consequences of the climate crisis and drastically increasing antibiotic resistances."

The HIOH will house three research departments, namely "Ecology and Emergence of Zoonotic Diseases" headed by Fabian Leendertz and the departments "Epidemiology and Ecology of Antimicrobial Resistance" and "Pathogen Evolution", which are already in the appointment phase. In addition, three junior research groups and two core units will complement these departments. "I would like to get the new colleagues on board as soon as possible so that we can jointly bring our concept to life," says Leendertz. "Especially for our research approach, close collaboration and continuous cross-cutting data analysis is crucial to be able to quickly and efficiently bring results into application."

Eröffnungsfeier des Helmholtz-Instituts für One Health (HIOH)

Eröffnungsfeier des Helmholtz-Instituts für One Health (HIOH): 1. Reihe v.l.n.r. Bettina Martin, Bettina Stark-Watzinger, Fabian Leendertz, Otmar D. Wiestler; 2. Reihe v.l.n.r. Thomas C. Mettenleiter, Karlhans Endlich, Katharina Riedel, Dirk Heinz © Universität Greifswald/Laura Schirrmeister © Universität Greifswald/Laura Schirrmeister

One particular focus is on prevention, i.e. preventing disease outbreaks and strengthening the pandemic preparedness. Important questions are, for example, where exactly the transmission of pathogens between humans and animals takes place, what the local risks are and which pathogens occur at all. Africa's tropics and Mecklenburg-Western Pomerania's cultural landscape serve as model regions, both of which are characterised by a good proportion of agriculture and hunting – albeit in traditionally very different ways. "In both regions, we can take a comparative look at which pathogens with which antibiotic resistances exist in people, animals and the environment and how the contacts take place. Together with the local people, we then want to derive specific hygiene measures adapted to their way of life, for example," says Leendertz. Here, too, the great importance of interdisciplinarity is evident: "We people have to learn to listen to each other so that we can find solutions on a local as well as global level." So the One Health approach must also find its way even more into university teaching and also into school education. "We have a clear educational mission to bring more attention to the One Health idea - and we want to fulfil this mission with the HIOH," says Leendertz.

 

In addition to the boards of the founding partners and the President of the Helmholtz Association, Prof Otmar D. Wiestler, the Federal Minister of Education and Research, Bettina Stark-Watzinger, and the State Minister of Science, Culture, Federal and European Affairs, Bettina Martin, attended the founding ceremony, among others. Dr Chikwe Ihekweazu, Deputy Director General of the World Health Organisation (WHO), and Prof Lothar Wieler, President of the Robert Koch Institute (RKI), sent video messages. The founding is followed by a scientific meeting, the One Health Conference 2022, on 27 and 28 April 2022.

Further information about the Institute and the research approach "One Health" can be found here:

Website of the site on the HZI website
One Health Research in Greifswald
HIOH fact sheet

The founding partners:

THE HELMHOLTZ CENTRE FOR INFECTION RESEARCH:

At the Helmholtz Centre for Infection Research (HZI), scientists study the mechanisms of infections and the defense against them. Understanding what makes bacteria or viruses into pathogens will hold the key to developing new medicines and vaccines. The HZI is a member of the German Centre for Infection Research (DZIF). Further information: https://www.helmholtz-hzi.de/en/

 

THE UNIVERSITY OF GREIFSWALD:

The University of Greifswald is one of the oldest universities in Germany and the Baltic Sea region. It maintains exchange relations with over 200 universities worldwide. International students and academics come from over 90 different countries. The university offers outstanding study conditions in modern buildings with an excellent infrastructure for research-oriented teaching. The university's scientists have access to an exceptional research infrastructure, including two inter-faculty research buildings of national importance and a (meta-)proteomics platform. Infection research at the university is based on interdisciplinary and cross-faculty research networks that deal with important bacterial pathogens, the diagnosis and therapy of infections, bacto-viral co-infections, the spread of antimicrobial resistances, human and environmental microorganisms and bats as a potential pathogen reservoir. https://www.uni-greifswald.de/en/

GREIFSWALD UNIVERSITY MEDICINE:

The hallmarks of Greifswald University Medicine are the complementary linking of the research foci of Community Medicine and Molecular Medicine and the resulting Greifswald approach to Individualised Medicine (GANI_MED). Currently, 608 staff are employed in research and teaching. They teach 1,370 students of human medicine and 270 students of dental medicine. https://www.medizin.uni-greifswald.de/en/home/

FRIEDRICH-LOEFFLER-INSTITUT, FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH (FLI):

As Federal Research Institute for Animal Health, the Friedrich-Loeffler-Institut (FLI) addresses farm animal health and welfare. The work aims at the prevention, diagnostics and control of animal diseases, the improvement of animal welfare and animal nutrition as well as the preservation and use of farm animal genetic resources. https://www.fli.de/en/startpage/

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Eindrücke vom Neujahrsempfang

HIRI-Direktor Jörg Vogel ließ die Höhepunkte des Jahres 2022 Revue passieren und gab einen Ausblick auf das Jahr 2023.